PPP1R9B - protein phosphatase 1 regulatory subunit 9B Gene

Also Known as Spn; SPINO; PPP1R6; PPP1R9

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84687

About PPP1R9B

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,133,737-50,150,677 (from NCBI)

This gene has 2 transcripts (splice variants), 272 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 26.2), spleen (RPKM 25.4) and 24 other tissues.

Summary

This gene encodes a scaffold protein that functions as a regulatory subunit of protein Phosphatase 1a. Expression of this gene is particularly high in dendritic spines, suggesting that the encoded protein may play a role in receiving signals from the central nervous system. The encoded protein has putative tumor suppressor function and decreased expression has been observed in tumors. [provided by RefSeq, Feb 2014]

PPP1R9B Products (1)

mRNA Protein Name
NM_032595.5 NP_115984.3 neurabin-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11278317 GOA
Biological Process GO Annotation Evidence References Source
involved in cell migration IMP
IMP: Inferred from mutant phenotype
19151759 GOA
involved in filopodium assembly IMP
IMP: Inferred from mutant phenotype
19151759 GOA
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
11278317 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11278317 GOA
located in filopodium IDA
IDA: Inferred from direct assay
19151759 GOA
located in lamellipodium IDA
IDA: Inferred from direct assay
19151759 GOA
located in nucleoplasm IMP
IMP: Inferred from mutant phenotype
11278317 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
19151759 GOA
located in ruffle membrane IDA
IDA: Inferred from direct assay
19151759 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R9B Protein Structure

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (496 - 576)

  • 0
  • 200
  • 400
  • 600
  • 815 a.a.
Protein Preferred Names Protein Names

neurabin-2

  • neurabin-II

PPP1R9B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PPP1R9B Q96SB3 PPP1CB Homo sapiens P62140
Anti Bait CoIP
25785436
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Limbic Encephalitis
Ventricular Tachycardia, Catecholaminergic Polymorphic, 2

  • Catecholaminergic Polymorphic Ventricular Tachycardia 2

  • CPVT2

  • Vtsip

  • Bidirectional Tachycardia

  • Stress-Induced Polymorphic Ventricular Tachycardia

  • Ventricular Tachycardia, Stress-Induced Polymorphic

  • Cvpt2

  • Double Tachycardia Induced By Catecholamines

  • Malignant Paroxysmal Ventricular Tachycardia

  • Multifocal Ventricular Premature Beats

  • Paroxysmal Ventricular Fibrillation

  • Syncopal Paroxysmal Tachycardia

  • Syncopal Tachyarythmia

  • Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 2

  • Ventricular Tachycardia, Catecholaminergic Polymorphic, 1

  • Multifocal Pvcs

  • Multifocal Premature Ventricular Beats

  • Paroxysmal Familial Ventricular Fibrillation
Aspirin Allergy

  • Acetylsalicylic Acid Allergy

  • Asa Allergy
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11006 PPP1R9B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PPP1R9B RGD RGD:632281
Mus musculus PPP1R9B MGD MGI:2387581
Canis familiaris PPP1R9B VGNC VGNC:44903
Bos taurus PPP1R9B VGNC VGNC:106876
Felis catus PPP1R9B VGNC VGNC:69006
Macaca mulatta PPP1R9B VGNC VGNC:76372
Others PPP1R9B NCBI