RENBP - renin binding protein Gene

Also Known as RBP; RNBP

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 5973

About RENBP

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:153,935,269-153,944,643 (from NCBI)

This gene has 10 transcripts (splice variants) and 175 orthologues. Broad expression in kidney (RPKM 29.7), spleen (RPKM 23.5) and 18 other tissues.

Summary

The gene product inhibits Renin activity by forming a dimer with Renin, a complex known as high molecular weight Renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with Renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. [provided by RefSeq, Jul 2008]

RENBP Products (1)

mRNA Protein Name
NM_002910.6 NP_002901.2 N-acylglucosamine 2-epimerase

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables N-acylglucosamine 2-epimerase activity IDA
IDA: Inferred from direct assay
9990133 GOA
enables N-acylglucosamine 2-epimerase activity IMP
IMP: Inferred from mutant phenotype
10502668 GOA
enables identical protein binding IDA
IDA: Inferred from direct assay
9990133 GOA
enables peptidase inhibitor activity IDA
IDA: Inferred from direct assay
9990133 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RENBP Protein Structure

GlcNAc_2-epim

GlcNAc_2-epim: N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) (47 - 386)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 427 a.a.
Protein Preferred Names Protein Names

N-acylglucosamine 2-epimerase

  • AGE

RENBP Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
RENBP P51606 SCML1 Homo sapiens Q9UN30-2
Y2H Prey Pooling
32296183
Intra
RENBP P51606 SCML1 Homo sapiens Q9UN30-2
Validated Y2H
32296183
Intra
RENBP P51606 SCML1 Homo sapiens Q9UN30-2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Nemaline Myopathy 1

  • Cap Myopathy 1

  • NEM1

  • Nemaline Myopathy 1, Autosomal Dominant Or Recessive

  • Nemaline Myopathy, Type 1

  • CAPM1

  • Cap Disease

  • Cap Myopathy Tpm3-Related

  • Nemaline Myopathy 1 Autosomal Dominant Or Recessive

  • Myopathy, Nemaline, Type 1

  • Cap Myopathy
Colorblindness, Partial, Protan Series

  • Protanopia

  • Red Color Blindness

  • Protan Defect

  • CBP

  • Red Colorblindness

  • Colorblindness, Protan

  • Color Blindness, Red
Red-Green Color Blindness

  • Deutan Defect

  • Deuteranopia

  • Reduced Red-Green Discrimination

  • Color Blindness, Red-Green

  • Colorblindness, Partial, Deutan Series
Sialuria

  • Sialuria, French Type

  • French Type Sialuria

  • Sialuria French Type

  • Sialic Acid Storage Disease

  • Sialic Acid Storage Disease, Finnish Type

  • Infantile Sialic Acid Storage Disease
Hypertension, Essential

  • Essential Hypertension

  • Hypertension

  • High Blood Pressure

  • Hypertension, Essential, Susceptibility To

  • Hypertensive Disease

  • Primary Hypertension

  • EHT

  • Hypertension, Salt-Sensitive Essential, Susceptibility To

  • Hyperpiesia

  • Idiopathic Hypertension

  • Hypertensive Disorder

  • Hypertension, Essential, Susceptibility To, 3

  • Hypertension, Essential 3

  • Hypertension, Essential, Salt-Sensitive

  • Hypertension, Essential, Susceptibility To, 6

  • Hypertension, Essential 6

  • Hypertension, Salt-Sensitive Essential

  • Hypertension, Susceptibility To

  • Hypertension, Essential, Susceptibility To, 4

  • Hypertension, Essential 4

  • Hypertension, Essential, Susceptibility To, 2

  • Hypertension, Essential 2

  • Hypertension, Essential, Susceptibility To, 1

  • Hypertension, Essential 1

  • Hypertension, Essential, Susceptibility To, 5

  • Hypertension, Essential 5

  • Htn

  • Vascular Hypertensive Disorder

  • Systemic Primary Arterial Hypertension

  • Hbp - [High Blood Pressure]

  • Systemic Arterial Hypertensive Disorder

  • Elevated Blood Pressure

  • Arterial Hypertension Nos

  • Hypertension Nos

  • Benign Hypertension

  • Systemic Arterial Hypertension

  • Systemic Hypertension

  • Artery Htn

  • Benign Htn

  • Vascular Htn

  • Vascular Hypertension

  • Cholesterol Hypertension

  • Cholesterol Htn

  • Idiopathic Htn

  • Malignant Hypertension

  • Malignant Htn

  • Raised Blood Pressure

  • Cardiovascular Hypertension

  • Primary Htn - [Hypertension]

  • High Arterial Tension

  • High Blood Pressure Disorder

  • Ht - [Hypertension]

  • Htn - [Hypertension]

  • Hypertensive Vascular Disease

  • Hypertensive Vascular Degeneration
Glutaric Acidemia I

  • Glutaryl-Coa Dehydrogenase Deficiency

  • GA1

  • Glutaric Acidemia Type 1

  • Glutaric Aciduria 1

  • Glutaric Aciduria Type 1

  • Glutaric Acidemia Type I

  • Glutaric Aciduria, Type 1

  • Glutaric Aciduria I

  • Ga I

  • Glutaricaciduria, Type I

  • Glutaryl-Coenzyme A Dehydrogenase Deficiency

  • Glutaric Academia Type 1

  • Glutaric Aciduria Type I

  • Ga-1

  • Gcdh Deficiency

  • Ga 1

  • Glutaric Acidemia 1

  • Gcdhd

  • Glutaric Aciduria, Type I

  • Glutaricaciduria I

  • Ga-I

  • Glutaricaciduria, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS11842 RENBP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus RENBP RGD RGD:621688
Bos taurus RENBP VGNC VGNC:33866
Macaca mulatta RENBP VGNC VGNC:76895
Mus musculus RENBP MGD MGI:105940
Canis familiaris RENBP VGNC VGNC:54185
Felis catus RENBP VGNC VGNC:69287
Others RENBP NCBI