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RENBP - renin binding protein Gene

Also Known as RBP; RNBP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5973

About RENBP

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:153,935,269-153,944,643 (from NCBI)

This gene has 10 transcripts (splice variants) and 175 orthologues. Broad expression in kidney (RPKM 29.7), spleen (RPKM 23.5) and 18 other tissues.

Summary

The gene product inhibits Renin activity by forming a dimer with Renin, a complex known as high molecular weight Renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with Renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. [provided by RefSeq, Jul 2008]

RENBP Products (1)

mRNA	Protein	Name
NM_002910.6	NP_002901.2	N-acylglucosamine 2-epimerase

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables N-acylglucosamine 2-epimerase activity	IDA IDA: Inferred from direct assay	9990133	GOA
enables N-acylglucosamine 2-epimerase activity	IMP IMP: Inferred from mutant phenotype	10502668	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	9990133	GOA
enables peptidase inhibitor activity	IDA IDA: Inferred from direct assay	9990133	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RENBP Protein Structure

GlcNAc_2-epim

0
100
200
300
400
427 a.a.

Protein Preferred Names	Protein Names
N-acylglucosamine 2-epimerase	AGE

RENBP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RENBP	P51606	SCML1	Homo sapiens	Q9UN30-2	Y2H Prey Pooling	32296183
Intra	RENBP	P51606	SCML1	Homo sapiens	Q9UN30-2	Validated Y2H	32296183
Intra	RENBP	P51606	SCML1	Homo sapiens	Q9UN30-2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Nemaline Myopathy 1	Cap Myopathy 1 NEM1 Nemaline Myopathy 1, Autosomal Dominant Or Recessive Nemaline Myopathy, Type 1 CAPM1 Cap Disease Cap Myopathy Tpm3-Related Nemaline Myopathy 1 Autosomal Dominant Or Recessive Myopathy, Nemaline, Type 1 Cap Myopathy
Colorblindness, Partial, Protan Series	Protanopia Red Color Blindness Protan Defect CBP Red Colorblindness Colorblindness, Protan Color Blindness, Red
Red-Green Color Blindness	Deutan Defect Deuteranopia Reduced Red-Green Discrimination Color Blindness, Red-Green Colorblindness, Partial, Deutan Series
Sialuria	Sialuria, French Type French Type Sialuria Sialuria French Type Sialic Acid Storage Disease Sialic Acid Storage Disease, Finnish Type Infantile Sialic Acid Storage Disease
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Glutaric Acidemia I	Glutaryl-Coa Dehydrogenase Deficiency GA1 Glutaric Acidemia Type 1 Glutaric Aciduria 1 Glutaric Aciduria Type 1 Glutaric Acidemia Type I Glutaric Aciduria, Type 1 Glutaric Aciduria I Ga I Glutaricaciduria, Type I Glutaryl-Coenzyme A Dehydrogenase Deficiency Glutaric Academia Type 1 Glutaric Aciduria Type I Ga-1 Gcdh Deficiency Ga 1 Glutaric Acidemia 1 Gcdhd Glutaric Aciduria, Type I Glutaricaciduria I Ga-I Glutaricaciduria, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11842	RENBP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RENBP	RGD	RGD:621688
Bos taurus	RENBP	VGNC	VGNC:33866
Macaca mulatta	RENBP	VGNC	VGNC:76895
Mus musculus	RENBP	MGD	MGI:105940
Canis familiaris	RENBP	VGNC	VGNC:54185
Felis catus	RENBP	VGNC	VGNC:69287
Others	RENBP	NCBI