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製品番号: HY-185453

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Mtb-IN-14

Mtb-IN-14 is a Mycobacterium tuberculosis (Mtb) malate synthase (GlcB) inhibitor with an IC₅₀ of 0.24 μM. Mtb-IN-14 inhibits growth of Mycobacterium tuberculosis. Mtb-IN-14 can be used for the research of tuberculosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 1224740-41-3
分子式: C₁₀H₇FO₄
分子量:210.16

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Mtb-IN-14 構造式

CAS 番号: 1224740-41-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Mtb-IN-14 (Compound 2) (20 min) potently inhibits purified C619A mutant Mtb malate synthase (GlcB) with an IC₅₀ of 0.24 μM^[1].
Mtb-IN-14 has a half-life of 12 days in cell growth media or buffer solutions^[1].
Mtb-IN-14 has a λ_max of 333 nm, reflecting reduced structural conjugation compared to the parent PDKA compound^[1].
Mtb-IN-14 inhibits growth of Mtb mc²-7000 with an MIC₉₉ of >200 μM in acetate-supplemented media and 200 μM in dextrose-supplemented media^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1224740-41-3
分子量 210.16
分子式 C₁₀H₇FO₄
SMILES

OC(/C(O)=C/C(C1=C(C=CC=C1)F)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Krieger IV, et al. Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase. Chem Biol. 2012;19(12):1556-1567. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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