Oleoylcarnitine
Based on 1 Customer Validation
Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.95%
- CAS 番号: 38677-66-6
- 分子式: C25H47NO4
- 分子量:425.64
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
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Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
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Human Endogenous Metabolite |
Oleoylcarnitine (AC18:1) (5, 25, 50 μM; 24, 48 hours) concentration significantly increases in the Dih10 cells with stable CPT2 knock down[1].
Oleoylcarnitine (5 μM, 24 hours) contributes directly to hepatocarcinogenesis by conferring stem cell properties to cancer cells through STAT3 activation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Dih 10 cells, HCC cells
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Concentration:5, 25, 50 µM
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Incubation Time:24, 48 hours
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Result:Enhanced the self-renewal of HCC cells through STAT3 activation.
Contributed directly to hepatocarcinogenesis.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MUP-uPA and PIK3CA Tg mice[1].
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Dosage:
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Administration:High-fat diet (HFD) for mice
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Result:Accumulated in HCC tissues and in the serum of HFD-fed mice.
化学情報
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CAS 番号 38677-66-6
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性状 Solid
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分子量 425.64
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分子式 C25H47NO4
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Color White to off-white
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SMILES
CCCCCCCC/C=C\CCCCCCCC(O[C@H](CC([O-])=O)C[N+](C)(C)C)=O
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別名
Oleoyl-L-carnitine
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 25 mg/mL (58.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (267 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3494 mL | 11.7470 mL | 23.4940 mL | 58.7351 mL |
| 5 mM | 0.4699 mL | 2.3494 mL | 4.6988 mL | 11.7470 mL | |
| 10 mM | 0.2349 mL | 1.1747 mL | 2.3494 mL | 5.8735 mL | |
| 15 mM | 0.1566 mL | 0.7831 mL | 1.5663 mL | 3.9157 mL | |
| 20 mM | 0.1175 mL | 0.5874 mL | 1.1747 mL | 2.9368 mL | |
| 25 mM | 0.0940 mL | 0.4699 mL | 0.9398 mL | 2.3494 mL | |
| 30 mM | 0.0783 mL | 0.3916 mL | 0.7831 mL | 1.9578 mL | |
| 40 mM | 0.0587 mL | 0.2937 mL | 0.5874 mL | 1.4684 mL | |
| 50 mM | 0.0470 mL | 0.2349 mL | 0.4699 mL | 1.1747 mL |
Oleoylcarnitine 関連分類
HY-113261 関連分類
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