P-LPK
P-LPK is a dodecapeptide that specifically targets SLC1A5, which is highly expressed on the membrane of colorectal cancer cells, with a Kd value of 1.19 μM. P-LPK has no intrinsic cell proliferation regulatory activity. Gallium-68-labeled P-LPK selectively accumulates at colorectal cancer tumor sites in xenograft mouse models. P-LPK can serve as a targeted carrier to deliver Camptothecin (HY-16560) to colorectal cancer cells, forming the conjugate P-LPK-CPT. P-LPK can be used in the research of colorectal cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C54H94N14O20S
- 分子量:1291.47
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
P-LPK (2 h) binds selectively to the cell membranes of human colorectal cancer cell lines Colo320HSR, HCT116 and LoVo, and its binding capacity is significantly higher than that of untransformed human colonic epithelial cells NCM460[1].
P-LPK binds selectively to human colorectal cancer (CRC) tissues, and its binding capacity is significantly higher than that to adjacent normal human colonic tissues[1].
P-LPK (overnight) colocalizes with SLC1A5 on the cell membrane of human colorectal cancer HCT116 cells, while mutations in P-LPK disrupt this interaction[1].
P-LPK (24-72 h) exhibits no cytotoxicity or proliferation-regulating effects on human colorectal cancer HCT116 cells, LoVo cells, and untransformed human colonic epithelial NCM460 cells[1].
P-LPK is mainly internalized into human colorectal cancer HCT116 cells via a clathrin-mediated endocytosis mechanism[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:BALB/c nude (female, 4 weeks old)[1]
-
Dosage:3.7 MBq (100 μCi, 0.1 nmol in 100 μl) (68Ga-P-LPK); unlabeled P-LPK (blocking experiment)
-
Administration:i.v.; single dose; pre-injection (blocking experiment)
-
Result:Showed remarkable accumulation in HCT116 tumors at all time points, with significantly higher tumor/non-tumor (T/NT) ratios compared to 68Ga-P-CON.
Demonstrated no significant accumulation in U87 tumors.
Dramatically attenuated 68Ga-P-LPK binding to HCT116 tumors when pre-injected as unlabeled P-LPK, significantly reducing T/NT ratios at 60 and 120 minutes.
化学情報
-
分子量 1291.47
-
分子式 C54H94N14O20S
-
配列
Leu-Pro-Lys-Thr-Val-Ser-Ser-Asp-Met-Ser-Leu-Asn
-
シーケンスの短縮
LPKTVSSDMSLN
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
P-LPK 関連分類
HY-P11756 関連分類
Powered by Bioz