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製品番号: HY-117828

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PF-04756956

PF-04756956 is a highly potent type 1 cholecystokinin receptor (CCK1R) agonist (EC₅₀=0.47 nM). PF-04756956 is promising for research of obesity and related metabolic disorders.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1228934-52-8
分子式: C₄₀H₃₉N₇O₂
分子量:649.78

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

PF-04756956 構造式

CAS 番号: 1228934-52-8

容量

価格（税別）

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数量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

PF-04756956 is a highly potent type 1 cholecystokinin receptor (CCK1R) agonist (EC₅₀=0.47 nM). PF-04756956 is promising for research of obesity and related metabolic disorders^[1].

Cholecystokinin Receptor アイソフォーム固有の製品をすべて表示 :

CCKAR
CCKBR

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.47 nM Compound: PF-04756956	Agonist activity at wild-type human CCK1R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis Agonist activity at wild-type human CCK1R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis	[PMID: 26654202]
CHO	IC₅₀	>1000 nM Compound: PF-04756956	Displacement of [125I-BDZ-1] from wild-type human CCK1R expressed in CHO cells after 60 mins by scintillation counter Displacement of [125I-BDZ-1] from wild-type human CCK1R expressed in CHO cells after 60 mins by scintillation counter	[PMID: 26654202]
CHO	IC₅₀	>1000 nM Compound: PF-04756956	Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter	[PMID: 26654202]
CHO	IC₅₀	14.7 nM Compound: 10e	Displacement of [125I]-CCK-2 from rat CCK1 receptor expressed in CHO cells after 90 mins by liquid scintillation counting Displacement of [125I]-CCK-2 from rat CCK1 receptor expressed in CHO cells after 90 mins by liquid scintillation counting	[PMID: 22424974]
CHO	IC₅₀	20.3 nM Compound: 10e	Displacement of [125I]-CCK-2 from human CCK1 receptor expressed in CHO cells after 90 mins by liquid scintillation counting Displacement of [125I]-CCK-2 from human CCK1 receptor expressed in CHO cells after 90 mins by liquid scintillation counting	[PMID: 22424974]
CHO	IC₅₀	35 nM Compound: PF-04756956	Displacement of [125I-CCK] from wild-type human CCK1R expressed in CHO cells after 60 mins by scintillation counter Displacement of [125I-CCK] from wild-type human CCK1R expressed in CHO cells after 60 mins by scintillation counter	[PMID: 26654202]

化学情報

CAS 番号 1228934-52-8
分子量 649.78
分子式 C₄₀H₃₉N₇O₂
SMILES

O=C1[C@@H](CC2=NNC3=C2C=CC=C3)C4=NN=C(C5=CC=CC=C5)N4C6=CC=CC=C6N1CC(N7[C@@H](CC8=CC(C)=CC(C)=C8)CCCC7)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Desai AJ, et al. Molecular Mechanism of Action of Triazolobenzodiazepinone Agonists of the Type 1 Cholecystokinin Receptor. Possible Cooperativity across the Receptor Homodimeric Complex. J Med Chem. 2015 Dec 24;58(24):9562-77. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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参考文献

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PF-04756956

Cholecystokinin Receptor アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

PF-04756956 関連分類

HY-117828 関連分類