ルテニウムレッド
Based on 16 publication(s) in Google Scholar
Ruthenium red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides. Ruthenium red is a L-type calcium current (ICa) blocker.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.95%
- CAS 番号: 11103-72-3
- 分子式: Cl6H42N14O2Ru3
- 分子量:786.35
-
保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Ruthenium red
More- Nature. 2026 Apr;652(8108):209-219. [Abstract]
- Nat Commun. 2024 Aug 27;15(1):7369. [Abstract]
- Adv Sci (Weinh). 2024 Nov 8:e2405705. [Abstract]
- Dev Cell. 2024 Jul 3:S1534-5807(24)00385-X. [Abstract]
- Small Methods. 2025 Mar;9(3):e2401144. [Abstract]
- Free Radic Biol Med. 2023 Aug 20:205:25-46. [Abstract]
- Cell Rep. 2023 Dec 2;42(12):113522. [Abstract]
- Front Pharmacol. 2022 May 17;13:855626. [Abstract]
- J Ovarian Res. 2025 Nov 29;19(1):4. [Abstract]
- Cell Calcium. 2026 May 23:136:103155. [Abstract]
- J Virol. 2025 Mar 18;99(3):e0217724. [Abstract]
- Biomed Res Int. 2021 May 14:2021:5565748. [Abstract]
- Biocell. 2026 Jan 23.
- J Ocean Univ China. 2026 25: 611-625.
- SSRN. 2025 Apr 10.
- bioRxiv. 2024 May 8:2024.05.07.592424. [Abstract]
Calcium Channel アイソフォーム固有の製品をすべて表示
More
生物活性
|
L-type calcium channel |
Ruthenium red staining of intracellular organelles and structures seemed to depend on the time of exposure to this agent, as well on the concentration used[2].
Ruthenium red efficiently blocks the L-type calcium current in a dose-dependent manner in in guinea-pig isolated ventricular heart cells, with EC50 of 0.8 μM[2].
Ruthenium red (10 μM) blocks the sarcoplasmic Ca2+ release channels or the mitochondrial Ca2+ uptake, and blocks 26.7 % of the sodium current, and slows its inactivation time-course in guinea-pig isolated ventricular heart cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 11103-72-3
-
性状 Solid
-
分子量 786.35
-
分子式 Cl6H42N14O2Ru3
-
Color Brown to black
-
SMILES
[NH3][Ru](O[Ru]([NH3])([NH3])([NH3])([NH3])O[Ru]([NH3])([NH3])([NH3])([NH3])[NH3])([NH3])([NH3])([NH3])[NH3].[6+].[Cl-].[6]
-
別名
Ruthenium red; Ammoniated ruthenium oxychloride
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (16)
-
Journal Impact Factor
-
Most Recent
-
Nature
2026 Apr;652(8108):209-219. PMID: 41781621 -
Nat Commun
2024 Aug 27;15(1):7369. PMID: 39191796 -
Adv Sci (Weinh)
Piezo1 Regulates Stiffness-Dependent DRG Axon Regeneration via Modifying Cytoskeletal Dynamics. [Abstract]2024 Nov 8:e2405705. PMID: 39514408 -
Dev Cell
GRP75-dependent mitochondria-ER contacts ensure cell survival during early mouse thymocyte development. [Abstract]2024 Jul 3:S1534-5807(24)00385-X. PMID: 38981469 -
Small Methods
An Integrated Microcurrent Delivery System Facilitates Human Parathyroid Hormone Delivery for Enhancing Osteoanabolic Effect. [Abstract]2025 Mar;9(3):e2401144. PMID: 39420694 -
Free Radic Biol Med
β-carotene targets IP3R/GRP75/VDAC1-MCU axis to renovate LPS-induced mitochondrial oxidative damage by regulating STIM1. [Abstract]2023 Aug 20:205:25-46. PMID: 37270031 -
Cell Rep
Cell-cell and cell-matrix adhesion regulated by Piezo1 is critical for stiffness-dependent DRG neuron aggregation. [Abstract]2023 Dec 2;42(12):113522. PMID: 38048221 -
Front Pharmacol
Resibufogenin Targets the ATP1A1 Signaling Cascade to Induce G2/M Phase Arrest and Inhibit Invasion in Glioma. [Abstract]2022 May 17;13:855626. PMID: 35656311 -
J Ovarian Res
M6A modification mediates CACNA1A stability to drive the progression of ovarian cancer by inhibiting ferroptosis. [Abstract]2025 Nov 29;19(1):4. PMID: 41316396 -
Cell Calcium
Drug repurposing DMSO from an old solvent to a new candidate for the treatment of colitis and sepsis in male mice. [Abstract]2026 May 23:136:103155. PMID: 42235215 -
J Virol
Seneca Valley virus induces mitochondrial apoptosis by activating ER stress or the PERK pathway based on Ca2+ transfer from ER to mitochondria. [Abstract]2025 Mar 18;99(3):e0217724. PMID: 39912666 -
Biomed Res Int
Gentiopicroside Produces Endothelium-Independent Vasodilation by Deactivating the PI3K/Akt/Rho-Kinase Pathway in Isolated Rat Thoracic Aorta. [Abstract]2021 May 14:2021:5565748. PMID: 34095301 -
-
-
-
bioRxiv
2024 May 8:2024.05.07.592424. PMID: 38766123
溶剤 & 溶解度
H2O : 10 mg/mL (12.72 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (288 KB)
-
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Lashanda N Waller, et al. Ruthenium red staining for ultrastructural visualization of a glycoprotein layer surrounding the spore of Bacillus anthracis and Bacillus subtilis. J Microbiol Methods. 2004 Jul;58(1):23-30. [Content Brief]
[2]. Claire O Malécot, et al. Ruthenium red as an effective blocker of calcium and sodium currents in guinea-pig isolated ventricular heart cells. Br J Pharmacol. 1998 Jun; 124(3): 465-472. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.2717 mL | 6.3585 mL | 12.7170 mL | 31.7925 mL |
| 5 mM | 0.2543 mL | 1.2717 mL | 2.5434 mL | 6.3585 mL | |
| 10 mM | 0.1272 mL | 0.6358 mL | 1.2717 mL | 3.1792 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Ruthenium red 関連分類
HY-103311 関連分類
Powered by Bioz