125 Results for "

DAP

" in MedChemExpress (MCE) Product Catalog:
Products (125)

125 Results for "DAP" in MCE Product Catalog:

36
36 Publications Verification
製品番号: HY-100714A
CAS 番号: 79055-68-8
純度:  99.94%
別名: D-APV; D-2-Amino-5-phosphonovaleric acid
Target:  

iGluR

研究分野:  

Neurological Disease

D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a Kd of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors .
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2
2 Cited Publications
製品番号: HY-P4931
CAS 番号: 720710-69-0
Target:  

MMP

研究分野:  

Cancer

Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a fluorescent peptide that is a quenched MMP peptide substrate. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 can be used for real-time quantification of MMP enzymatic activity. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is an elongated peptide of MMP substrate (FS-1) and is active against collagenases (MMP-1, MMP-8, MMP-13 ) and MT1-MMP with higher specificity constants than FS-1 . (Ex/Em=325 nm/400 nm)
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2
2 Cited Publications
製品番号: HY-P80351
別名: DAP1 antibody; GAP modifying protein 1 antibody; GMP 1 antibody; OFC10 antibody; PIC 1 antibody; PIC1 antibody; SENP2 antibody; Sentrin 1 antibody; Sentrin antibody; Small ubiquitin related modifier 1 antibody; Small ubiquitin-like modifier 1 antibody; Small ubiquitin-related modifier 1 antibody; SMT3 antibody; SMT3 homolog 3 antibody; SMT3 suppressor of mif two 3 homolog 1 antibody; SMT3, yeast, homolog 3 antibody; Smt3C antibody; SMT3H3 antibody; SUMO-1 antibody; SUMO1 antibody; SUMO1_HUMAN antibody; Ubiquitin homology domain protein PIC1 antibody; Ubiquitin Like 1 antibody; Ubiquitin like protein SMT3C antibody; Ubiquitin like protein UBL1 antibody; Ubiquitin-homology domain protein PIC1 antibody; Ubiquitin-like protein SMT3C antibody; Ubiquitin-like protein UBL1 antibody; UBL 1 antibody; UBL1 antibody

Host:  

Rabbit

Application:  

WB, ICC/IF, IHC-P, IP, FC, ChIP

Reactivity:  

Human, Mouse, Rat

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1
1 Cited Publications
製品番号: HY-P5524A
別名: Lauroyl-γ-D-glutamyl-meso-diaminopimelic acid hydrochloride; γ-D-glutamyl-meso-diaminopimelic acid hydrochloride
C12-iE-DAP hydrochloride (Lauroyl-γ-D-glutamyl-meso-diaminopimelic acid HYdrochloride) is a highly potent and selective NOD1 agonist, with an EC50 of 0.027 nM in HEK-Blue cells expressing human NOD1. C12-iE-DAP hydrochloride activates the NOD1/RIPK2 signaling pathway and its downstream p38 MAPK and NF-κB, induces the expression of inflammatory mediators such as IL6 and IL8, and exerts synergistic effects with TLR4, Dectin-1 or Mincle signaling. C12-iE-DAP hydrochloride can be used in studies related to vascular inflammation, tumor metastasis and neuroinflammation .
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1
1 Cited Publications
製品番号: HY-P10086
CAS 番号: 1289375-12-7
別名: Human TREM-1(213-221)
TREM-1 inhibitory peptide GF9 (Human TREM-1 (213-221)) is a TREM-1 inhibitor. TREM-1 inhibitory peptide GF9 blocks the TREM-1 signaling pathway via a ligand-independent mechanism, spontaneously inserts into the cell membrane to dissociate TREM-1 from DAP-12, and functions through the Signaling Chain Homooligomerization (SCHOOL) model. TREM-1 inhibitory peptide GF9 reduces the levels of TNFα, IL-1β, IL-6, and M-CSF. TREM-1 inhibitory peptide GF9 inhibits tumor growth, prolongs the survival of mice with pancreatic cancer models, ameliorates collagen-induced arthritis, and exerts protective effects on bone and cartilage simultaneously. TREM-1 inhibitory peptide GF9 can be used in research related to arthritis, pancreatic cancer, retinopathy, alcoholic liver disease, and liver cancer .
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製品番号: HY-P991220

Target:  

TREM receptor

研究分野:  

Neurological Disease

AL002 is a humanized monoclonal IgG1 antibody and a blood-brain barrier-permeable TREM2 modulator. AL002 binds to TREM2 on the surface of microglia, promotes TREM2 clustering and the formation of the TREM2-DAP12 complex, activates the TREM2 signaling pathway and PI3K cascade, and induces TREM2 internalization and degradation. AL002 is applicable to research related to Alzheimer's disease .
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製品番号: HY-P10375
CAS 番号: 1629665-96-8
Target:  

PD-1/PD-L1

研究分野:  

Inflammation/Immunology Cancer

BMS-986189 is a macrocyclic peptide PD-1/PD-L1 interaction with an IC50 of 1.03 nM inhibitor. BMS-986189 can be used for cancer research, such as human lung carcinoma cells L2987 .
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製品番号: HY-P1070A
別名: DAP amide, human TFA
Target:  

Amylin Receptor

研究分野:  

Metabolic Disease

Amylin, amide, human TFA, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. Amylin, amide, human TFA inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent .
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製品番号: HY-78931
CAS 番号: 160800-65-7
Target:  

ADC Linkers

研究分野:  

Cancer

Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.
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製品番号: HY-P1070
CAS 番号: 122384-88-7
別名: DAP amide, human
Target:  

Amylin Receptor

研究分野:  

Metabolic Disease

Amylin, amide, human, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. Amylin, amide, human inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent .
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製品番号: HY-P5523A
iE-DAP dihydrochloride is a Nod1 agonist. iE-DAP dihydrochloride activates NOD1, which in turn activates the NF-κB signaling pathway and MLCK signaling pathway, inducing cellular inflammatory responses and tight junction disruption. iE-DAP dihydrochloride downregulates the expression of ZO-1 and Occludin genes. iE-DAP dihydrochloride increases the secretion of IL-6, GRO-α, MCP-1, IL-8 and MIP-1β in term human trophoblast cell cultures. iE-DAP dihydrochloride triggers preterm birth in pregnant mice, reduces fetal body weight, and induces fetal inflammation. iE-DAP dihydrochloride can be used in studies related to mastitis and preterm birth .
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製品番号: HY-W008325
CAS 番号: 73259-81-1
Boc-L-Dap-OH is a Boc-protected derivative of L-2,3-diaminopropionic acid. Boc-L-Dap-OH is an important chiral amino acid derivative. Boc-L-Dap-OH can be generated via the Hofmann rearrangement of Boc-L-asparagine. Boc-L-Dap-OH serves as a starting material for the preparation of BIM analogs .
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製品番号: HY-W010922
CAS 番号: 162558-25-0
研究分野:  

Others

Fmoc-Dap (Boc)-OH is an amino acid derivative bearing the Fmoc protecting group. Fmoc-Dap (Boc)-OH supports Fmoc-based solid-phase peptide synthesis for the preparation of bicyclic tachykinin NK2 receptor antagonists .
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製品番号: HY-W250408
CAS 番号: 1352202-13-1
研究分野:  

Cancer

Fmoc-NMe-Val-Val-Dil-Dap-OH is an intermediate for preparing drug-linker conjugate MC-MMAF, which can be used for synthesis of ADC molecule .
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製品番号: HY-W010962
CAS 番号: 188970-92-5
研究分野:  

Others

Fmoc-Dap(Alloc)-OH is an alanine derivative .
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製品番号: HY-144022
CAS 番号: 96326-74-8
純度:  ≥98.0%
16:0 DAP is a cationic lipids that can be used for drug delivery, gene transfection and vaccine delivery .
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製品番号: HY-130961
CAS 番号: 1415246-54-6
純度:  98.52%
Target:  

ADC Linkers

研究分野:  

Cancer

Boc-Val-Dil-Dap-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
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製品番号: HY-160795
CAS 番号: 1369426-99-2
Target:  

ADC Linkers

研究分野:  

Cancer

Boc-NMe-Val-Val-Dil-Dap-OH is a linker, that can be used for ADC synthesis.
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製品番号: HY-P10950A
Target:  

PD-1/PD-L1

研究分野:  

Inflammation/Immunology Cancer

PD-L1 inhibitory peptide TFA is an inhibitor peptide targeting programmed cell death ligand 1 (PD-L1). PD-L1 inhibitory peptide TFA binds to PD-L1, relieving immunosuppression and restoring the antitumor activity of T cells. PD-L1 inhibitory peptide TFA is promising for research of cancers .
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製品番号: HY-164170
CAS 番号: 2321346-88-5
別名: pm-DAP
Target:  

Drug Intermediate

研究分野:  

Others

Photocaged DAP (pm-DAP) is a protected version of 2,3-Diaminopropionic acid (DAP) (HY-W013673). Photocaged DAP can produce 2,3-Diaminopropionic acid after photodeprotection. Photocaged DAP can be used as an intermediate to capture biosynthetic acylase .
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