seco-CBI dimer
seco-CBI dimer is a DNA alkylating agent and a prodrug of Duocarmycin, which can serve as a payload for synthesizing antibody-drug conjugates (ADCs). seco-CBI dimer binds to the minor groove of A-T-rich regions in DNA, alkylates the N3 position of adenine residues, and induces DNA strand breaks. seco-CBI dimer can be used in the research of non-Hodgkin's lymphoma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2592397-70-9
- 分子式: C41H36Cl2N4O5
- 分子量:735.65
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
ADC Payloads アイソフォーム固有の製品をすべて表示
More
生物活性
seco-CBI dimer-based ADCs potently inhibit the growth of CD22-positive lymphoma cells in vitro, with IC50 values ranging from 10 to 80 pM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 2592397-70-9
-
分子量 735.65
-
分子式 C41H36Cl2N4O5
-
SMILES
ClC[C@@H]1CN(C2=C1C3=C(C(O)=C2)C=CC=C3)C(/C=C/C4=C(C=C(C=C4)/C=C/C(N5C6=C([C@@H](C5)CCl)C7=C(C(O)=C6)C=CC=C7)=O)NC(CCN)=O)=O
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
seco-CBI dimer 関連分類
HY-185488 関連分類
Powered by Bioz