STING agonist-30
STING agonist-30 is a potent STING agonist. STING agonist-30 exhibits STING-dependent immune activation. STING agonist-30 has extensive inhibitory effects on various viruses, including the herpes simplex virus (HSV), rotavirus, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
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- CAS 番号: 2951078-67-2
- 分子式: C15H16N4O8
- 分子量:380.31
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | IC50 |
22.36 μM
Compound: 23
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Cytotoxicity against STING-deficient human 293T cells assessed as cell viability measured after 72 hrs by MTT assay
Cytotoxicity against STING-deficient human 293T cells assessed as cell viability measured after 72 hrs by MTT assay
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[PMID: 36758305] |
| HT-1080 | IC50 |
9.31 μM
Compound: 23
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Cytotoxicity against human HT-1080 cells assessed as cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human HT-1080 cells assessed as cell viability measured after 72 hrs by MTT assay
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[PMID: 36758305] |
| RAW264.7 | IC50 |
8.69 μM
Compound: 23
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Cytotoxicity against mouse RAW264.7 cells assessed as cell viability measured after 72 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells assessed as cell viability measured after 72 hrs by MTT assay
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[PMID: 36758305] |
| Vero | IC50 |
28.35 μM
Compound: 23
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Cytotoxicity against interferon production defective African green monkey Vero cells assessed as cell viability measured after 72 hrs by MTT assay
Cytotoxicity against interferon production defective African green monkey Vero cells assessed as cell viability measured after 72 hrs by MTT assay
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[PMID: 36758305] |
STING agonist-30 (compound 23; 20 μM; 5 h) increases TBK1 phosphorylation in wild-type HT1080 cells but not in HT1080 STING-KO cells[1].
STING agonist-30 (20 μM; 8 h) boosts interferon β (IFNβ) and TNF-α expression[1].
STING agonist-30 (0-20 μM; 5 h) activates both mouse and human STING in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT1080, THP1, BMDMs and MEFs
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Concentration:2.5, 5, 10, and 20 μM
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Incubation Time:5 hours
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Result:Induced obvious dimeric STING bands.
化学情報
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CAS 番号 2951078-67-2
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分子量 380.31
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分子式 C15H16N4O8
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SMILES
O=C(C1=CC=C(O1)[N+]([O-])=O)NCCCCCNC(C2=CC=C(O2)[N+]([O-])=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
STING agonist-30 関連分類
HY-149267 関連分類
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