STING agonist-31
STING agonist-31 is a STING agonist, with EC50 values of 0.24 and 39.51 μM for h-STING and m-STING. STING agonist-31 has antitumor efficiency.
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- CAS 番号: 2719001-44-0
- 分子式: C43H51N15O6
- 分子量:873.96
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
STING agonist-31 (Compound 40) activates h-STING and m-STING with EC50 values of 0.24 and 39.51 μM[1].
STING agonist-31 (0-10 μM, 24 h) activates the ISG signaling and NF-κB signaling[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
STING agonist-31 (1 mg/kg, i.v., rats) shows T1/2: 0.697 h, AUClast: 678 h•ng/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice models bearing orthotopic transplanted breast tumor (4T1) or subcutaneous transplanted colon tumor (CT26)[1]
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Dosage:10 mg/kg
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Administration:i.v., at days 1, 4, and 7
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Result:Inhibited tumor Growth.
化学情報
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CAS 番号 2719001-44-0
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分子量 873.96
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分子式 C43H51N15O6
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SMILES
O=C(C1=CC(C)=NN1CC)NC2=NC3=CC(C(N)=O)=CC(OCCCN4CCOCC4)=C3N2C/C=C/CN5C6=C(OC)C=C(C7=NN=CN7)C=C6N=C5NC(C8=CC(C)=NN8CC)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
STING agonist-31 関連分類
HY-153546 関連分類
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