STING-IN-5
Based on 1 Customer Validation
STING-IN-5 is a potent STING inhibitor, inhibiting LPS-induced NO synthesis in macrophages with an IC50 value of 1.15 μM. STING-IN-5 inhibits the inflammatory response. STING-IN-5 can be used to research anti-inflammatory diseases and sepsis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.89%
- CAS 番号: 2920064-17-9
- 分子式: C47H67NO9S2
- 分子量:854.17
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保管条件:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
STING-IN-5 (compound 30) (40 μM; 24 h) exhibits less effect on RAW264.7 cell viability[1].
STING-IN-5 (2.5 and 5 μM; 2 h) inhibits NO production in LPS-stimulated RAW264.7 with inhibition rate of 69.28 ± 2.36 and 78.66 ± 2.73 at 2.5 and 5 μM, respectively, and exhibits IC50 of 1.15 ± 0.15 μM[1].
STING-IN-5 (0.5-2 μM; 2 h) suppresses STING, as well as TBK1/IRF3/NF-κB activation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7
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Concentration:40 μM
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Incubation Time:24 h
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Result:Exhibited less effect on RAW264.7 cell viability of 91.08 ± 1.09%
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Cell Line:RAW264.7 (stimulated by LPS for 6 h)
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Concentration:0.5, 1 and 2 μM
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Incubation Time:2 h
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Result:Significantly inhibited the protein expression of STING and the phosphorylation of the downstream targets TBK1, IRF3, p65, and IκB in a concentration-dependent manner.
Pharmacokinetic Parameters of STING-IN-5 in male Sprague-Dawley rats[1].
| Tmax (h) | Cmax (ng/mL) | AUC0-t (ng/mL·h) | AUC0-∞ (ng/mL·h) | T1/2 (h) | MRT0-t (h) | MRT0-∞ (h) |
| 1 | 66.52 | 81.08 | 135.7 | 1.11 | 0.99 | 2.02 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male BALB/c mice (6-8 weeks; acute liver injury induced by injection of 10 mg/kg LPS)[1]
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Dosage:1.25, 2.5, 5 mg/kg
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Administration:i.g.; once daily; for 3 days
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Result:Significantly improved pathological changes including disorderly arranged liver cells, blurred boundaries, congested hepatic sinusoids, swollen hepatocytes, a small number of hepatocytes were necrotic, and inflammatory cells infiltrated local areas.
Significantly reduced the levels of AST, ALT, and ALP (liver function specific indicators).
化学情報
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CAS 番号 2920064-17-9
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性状 Solid
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分子量 854.17
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分子式 C47H67NO9S2
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Color White to off-white
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SMILES
C[C@H]([C@H](OC(CCSSCCC(NOCC=C)=O)=O)CC[C@@]1([C@@]2([C@@H](C[C@]3(/C4=C(CC/C=C(C)/C)\C(OCC5=CC=CC=C5)=O)[H])O)[H])C)[C@@]1(CC[C@]2(C)[C@@]3(C)C[C@@H]4OC(C)=O)[H]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶剤 & 溶解度
DMSO : 100 mg/mL (117.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1707 mL | 5.8536 mL | 11.7073 mL | 29.2682 mL |
| 5 mM | 0.2341 mL | 1.1707 mL | 2.3415 mL | 5.8536 mL | |
| 10 mM | 0.1171 mL | 0.5854 mL | 1.1707 mL | 2.9268 mL | |
| 15 mM | 0.0780 mL | 0.3902 mL | 0.7805 mL | 1.9512 mL | |
| 20 mM | 0.0585 mL | 0.2927 mL | 0.5854 mL | 1.4634 mL | |
| 25 mM | 0.0468 mL | 0.2341 mL | 0.4683 mL | 1.1707 mL | |
| 30 mM | 0.0390 mL | 0.1951 mL | 0.3902 mL | 0.9756 mL | |
| 40 mM | 0.0293 mL | 0.1463 mL | 0.2927 mL | 0.7317 mL | |
| 50 mM | 0.0234 mL | 0.1171 mL | 0.2341 mL | 0.5854 mL | |
| 60 mM | 0.0195 mL | 0.0976 mL | 0.1951 mL | 0.4878 mL | |
| 80 mM | 0.0146 mL | 0.0732 mL | 0.1463 mL | 0.3659 mL | |
| 100 mM | 0.0117 mL | 0.0585 mL | 0.1171 mL | 0.2927 mL |
STING-IN-5 関連分類
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