Tau-aggregation-IN-5
Tau-aggregation-IN-5 is a Tau-aggregation inhibitor (EC50 = 0.31 μM). Tau-aggregation-IN-5 targets P4HB covalently and activates mild ER stress. Tau-aggregation-IN-4 can be used for the study of neurodegenerative disorders such as Alzheimer’s and Pick’s diseases.
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- CAS 番号: 1283397-08-9
- 分子式: C15H13N3O
- 分子量:251.28
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Tau-aggregation-IN-5 (Compound 2a) (0.008-10 μM,) dose-dependently clears tau accumulation in human induced pluripotent stem cell (hiPSC)-derived neurons, with an EC50 of 190 nM and a maximum clearance rate exceeding 90%[1].
Tau-aggregation-IN-5 (3 μM, 24 h) does not affect the level of non-aggregated tau protein in SH-SY5Y cells[1].
Tau-aggregation-IN-5 (10 μM, 6 hours) results in significant changes in the expression of 590 genes in 22,537 transcripts in SH-SY5Y cells, including ERO1B, HSPA5, and HERPUD1[1].
Tau-aggregation-IN-5 (10 μM, 2-6 h) significantly upregulates the ERAD-associated protein HERPUD1 in SH-SY5Y cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1283397-08-9
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分子量 251.28
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分子式 C15H13N3O
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SMILES
O=C(C1=CNC2=C1C=CC(N)=C2)NC3=CC=CC=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Tau-aggregation-IN-5 関連分類
HY-176936 関連分類
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