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TRK-IN-30

TRK-IN-30 (Compound C11) is the inhibitor for tropomyosin receptor kinase (TRK) that inhibits TRKA, TRKB and TRKC and drug resistant mutant TRKAG595R with an IC50 of 1.8, 0.98, 3.8, and 54 nM, respectively. TRK-IN-30 inhibits the activation of the downstream PI3K/AKT and MEK/ERK signaling pathways. TRK-IN-30 inhibits the colony formation and cell migration of Km-12, arrests the cell cycle at G0/G1 phase, and induces apoptosis in Km-12.

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  • 分子式: C24H21N5O3
  • 分子量:427.46
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • TRK-IN-30 Chemical Structure
    TRK-IN-30 構造式
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  • TRK-IN-30 Chemical Structure
    TRK-IN-30 Chemical Structure
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  • TRK-IN-30