2. GPCR/G Protein Neuronal Signaling
  3. Amylin Receptor CGRP Receptor
  4. KBP-042

KBP-042 is an orally active amylin receptor activator, a calcitonin receptor activator. KBP-042 induces sustained weight loss, reduces adipose tissue mass, lowers hepatic lipid deposition, increases plasma adiponectin, decreases plasma leptin, and reduces plasma glucose-dependent insulinotropic peptide levels. KBP-042 can be used for the research of obesity and insulin resistance.

For research use only. We do not sell to patients.

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KBP-042

KBP-042 Chemical Structure

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Description

KBP-042 is an orally active amylin receptor activator, a calcitonin receptor activator. KBP-042 induces sustained weight loss, reduces adipose tissue mass, lowers hepatic lipid deposition, increases plasma adiponectin, decreases plasma leptin, and reduces plasma glucose-dependent insulinotropic peptide levels. KBP-042 can be used for the research of obesity and insulin resistance[1].

In Vivo

KBP-042 (0.625-10 μg/kg; s.c.; daily; 56 days) induces sustained weight loss (up to 20%), reduces adipose tissue and hepatic lipid accumulation (significantly at 2.5 μg/kg and 10 μg/kg for hepatic TAG), improves glucose tolerance, and increases insulin sensitivity (82% increase in glucose infusion rate) in obese, insulin-resistant rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley (male, 6 weeks old at study start, fed 60% fat kcal high-fat diet for 10 weeks to induce obesity and prediabetic status)[1]
Dosage: 0.625-10 μg/kg (8-week treatment); 5 μg/kg (hyperinsulinemic-euglycemic clamp)
Administration: s.c.; daily; 56 days (8-week treatment); 21 days (hyperinsulinemic-euglycemic clamp)
Result: Induced a dose-dependent, sustained weight loss up to 20% compared to high-fat diet vehicle; caused significant weight reduction at 2.5, 5, and 10 μg/kg vs. vehicle. Reduced epididymal and perirenal adipose tissue weights significantly at 10 μg/kg; reduced perirenal adipose tissue also at 2.5 and 5 μg/kg. Reduced hepatic triacylglycerol accumulation significantly at 2.5 μg/kg and 10 μg/kg. Increased plasma adiponectin significantly at 1.25, 2.5, 5, and 10 μg/kg; reduced plasma leptin significantly at 10 μg/kg. Showed impaired glucose tolerance (increased total area under the curve) at 10 μg/kg in acute OGTT, but reduced glucose total area under the curve at 2.5, 5, and 10 μg/kg vs. vehicle after 3 weeks of chronic treatment; improved glucose tolerance at 5 and 10 μg/kg after 7 weeks. Reduced insulin total area under the curve at 1.25-10 μg/kg after 3 weeks of IVGTT and at 2.5 and 5 μg/kg after 7 weeks while maintaining glucose tolerance. Increased glucose infusion rate by 82% vs. high-fat diet vehicle (and 27% vs. normal diet controls) during hyperinsulinemic-euglycemic clamp at 5 μg/kg.
Molecular Weight

3483.93

Formula

C149H244N44O48S2
Sequence

Ac-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asp-Val-Gly-Ala-Asn-Ala-Pro-NH2 (Disulfide bridge: Cys1-Cys7)
Sequence Shortening

Ac-CSNLSTCVLGKLSQELHKLQTYPRTDVGANAP-NH2 (Disulfide bridge: Cys1-Cys7)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KBP-042 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KBP-042KBP042KBP 042Amylin ReceptorCGRP ReceptorAMYRCalcitonin gene-related peptide receptorcalcitonin receptoradipose tissueinsulin resistanceglucose-dependent insulinotropic peptideplasma leptinplasma adiponectinhepatic lipid depositiongastric emptyingamylin receptorobesityInhibitorinhibitorinhibit

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