Hmces - 5-hydroxymethylcytosine (hmC) binding, ES cell specific Gene

Also Known as Srap1; 8430410A17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 232210

Summary

Enables single-stranded DNA binding activity. Involved in double-strand break repair via alternative nonhomologous end joining and positive regulation of isotype switching. Predicted to be located in replication fork. Is expressed in several structures, including adipose tissue; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human HMCES (5-hydroxymethylcytosine binding, ES cell specific). [provided by Alliance of Genome Resources, Apr 2022]

Hmces Products (1)

mRNA Protein Name
NM_173737.2 NP_776098.1 abasic site processing protein HMCES

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
31806351 MGI
Biological Process GO Annotation Evidence References Source
involved in double-strand break repair via alternative nonhomologous end joining IDA
IDA: Inferred from direct assay
31806351 MGI
involved in positive regulation of isotype switching IDA
IDA: Inferred from direct assay
31806351 MGI
involved in somatic hypermutation of immunoglobulin genes IDA
IDA: Inferred from direct assay
35450882 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

abasic site processing protein HMCES

  • ES cell-specific 5hmC-binding protein

  • SRAP domain-containing protein 1

  • UPF0361 protein C3orf37 homolog

  • embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein

  • peptidase HMCES

  • putative endonuclease HMCES

  • putative peptidase SRAPD1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06225 HMCES Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20420 Hmces Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26929 Hmces Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hmces NCBI NCBI:56941