HMCES - 5-hydroxymethylcytosine binding, ES cell specific Gene

Also Known as DC12; SRAPD1; C3orf37

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56941

About HMCES

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:129,278,832-129,306,186 (from NCBI)

This gene has 8 transcripts (splice variants) and 194 orthologues. Ubiquitous expression in lymph node (RPKM 40.1), testis (RPKM 20.9) and 24 other tissues.

Summary

Enables single-stranded DNA binding activity. Involved in cellular response to DNA damage stimulus and protein-DNA covalent cross-linking. Located in replication fork. [provided by Alliance of Genome Resources, Apr 2022]

HMCES Products (6)

mRNA Protein Name
NM_001006109.1 NP_001006109.1 abasic site processing protein HMCES isoform a
NM_001363881.1 NP_001350810.1 abasic site processing protein HMCES isoform b
NM_001370343.1 NP_001357272.1 abasic site processing protein HMCES isoform a
NM_001370344.1 NP_001357273.1 abasic site processing protein HMCES isoform a
NM_001370345.1 NP_001357274.1 abasic site processing protein HMCES isoform c
NM_020187.3 NP_064572.2 abasic site processing protein HMCES isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables DNA-(abasic site) binding IDA
IDA: Inferred from direct assay
30554877 GOA
NOT enables DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
IDA: Inferred from direct assay
30554877 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
30554877 GOA
enables protein-DNA covalent cross-linking activity IDA
IDA: Inferred from direct assay
30554877 GOA
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
30554877 GOA
Biological Process GO Annotation Evidence Références Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
30554877 GOA
involved in interstrand cross-link repair IDA
IDA: Inferred from direct assay
33321094 GOA
involved in protein-DNA covalent cross-linking repair IDA
IDA: Inferred from direct assay
37519246 GOA
involved in somatic hypermutation of immunoglobulin genes IDA
IDA: Inferred from direct assay
35450882 GOA
Cellular Component GO Annotation Evidence Références Source
is active in replication fork IDA
IDA: Inferred from direct assay
30554877 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HMCES Protein Structure

SRAP

SRAP: SOS response associated peptidase (SRAP) (1 - 264)

  • 0
  • 100
  • 200
  • 300
  • 354 a.a.
Protein Preferred Names Protein Names

abasic site processing protein HMCES

  • 5-hydroxymethylcytosine (hmC) binding, ES cell-specific

Related Diseases

Diseases Alias
Brachydactyly, Type A4

  • Brachymesophalangy Ii And V

  • Temtamy Type Brachydactyly

  • Brachydactyly Type A4

  • BDA4

  • Brachymesophalangy 2 And 5

  • Brachydactyly Temtamy Type

  • Brachydactyly, Temtamy Type
Ruijs-Aalfs Syndrome

  • Progeroid Features-Hepatocellular Carcinoma Predisposition Syndrome

  • RJALS
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS06225 HMCES Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20420 Hmces Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26929 Hmces Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus HMCES VGNC VGNC:102606
Rattus norvegicus HMCES RGD RGD:1559800
Mus musculus HMCES MGD MGI:1914053
Macaca mulatta HMCES VGNC VGNC:73436
Bos taurus HMCES VGNC VGNC:29871
Canis familiaris HMCES VGNC VGNC:41705
Others HMCES NCBI