2. Gene
  3. HMCES - 5-hydroxymethylcytosine binding, ES cell specific Gene

HMCES - 5-hydroxymethylcytosine binding, ES cell specific Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DC12; SRAPD1; C3orf37

Gene ID: 56941 | Gene type: protein coding

About HMCES

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:129,278,832-129,306,186 (from NCBI)

This gene has 8 transcripts (splice variants) and 194 orthologues. Ubiquitous expression in lymph node (RPKM 40.1), testis (RPKM 20.9) and 24 other tissues.

Summary

Enables single-stranded DNA binding activity. Involved in cellular response to DNA damage stimulus and protein-DNA covalent cross-linking. Located in replication fork. [provided by Alliance of Genome Resources, Apr 2022]

HMCES Products(6)

mRNA Protein Name
NM_001006109.1 NP_001006109.1 abasic site processing protein HMCES isoform a
NM_001363881.1 NP_001350810.1 abasic site processing protein HMCES isoform b
NM_001370343.1 NP_001357272.1 abasic site processing protein HMCES isoform a
NM_001370344.1 NP_001357273.1 abasic site processing protein HMCES isoform a
NM_001370345.1 NP_001357274.1 abasic site processing protein HMCES isoform c
NM_020187.3 NP_064572.2 abasic site processing protein HMCES isoform a

HMCES Protein Structure

SRAP

SRAP: SOS response associated peptidase (SRAP) (1 - 264)

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  • 354 a.a.
Protein Preferred Names Protein Names

abasic site processing protein HMCES

5-hydroxymethylcytosine (hmC) binding, ES cell-specific

Related Diseases

Diseases Alias
Brachydactyly, Type A4

Brachymesophalangy Ii And V

Temtamy Type Brachydactyly

Brachydactyly Type A4

BDA4

Brachymesophalangy 2 And 5

Brachydactyly Temtamy Type

Brachydactyly, Temtamy Type
Ruijs-Aalfs Syndrome

Progeroid Features-Hepatocellular Carcinoma Predisposition Syndrome

RJALS
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06225 HMCES Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus HMCES VGNC VGNC:102606
Rattus norvegicus HMCES RGD RGD:1559800
Mus musculus HMCES MGD MGI:1914053
Macaca mulatta HMCES VGNC VGNC:73436
Bos taurus HMCES VGNC VGNC:29871
Canis familiaris HMCES VGNC VGNC:41705