DDAH1 - dimethylarginine dimethylaminohydrolase 1 Gene

Also Known as DDAH; DDAHI; DDAH-1; HEL-S-16

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23576

About DDAH1

Cytogenetic location: 1p22.3 Genomic coordinates (GRCh38): 1:85,318,485-85,578,200 (from NCBI)

This gene has 3 transcripts (splice variants), 213 orthologues and 1 paralogue. Broad expression in kidney (RPKM 34.4), brain (RPKM 28.2) and 21 other tissues.

Summary

This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008]

DDAH1 Products (3)

mRNA Protein Name
NM_001134445.2 NP_001127917.1 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform 2
NM_001330655.2 NP_001317584.1 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform 3
NM_012137.4 NP_036269.1 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform 1

DDAH1 Protein Structure

Amidinotransf

Amidinotransf: Amidinotransferase (23 - 279)

  • 0
  • 100
  • 200
  • 285 a.a.
Protein Preferred Names Protein Names

N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

  • NG, NG-dimethylarginine dimethylaminohydrolase

Recombinant DDAH1 Proteins

Cat. No. Product Name Accession Purity
HY-P79232 DDAH1 Protein, Human (His, Myc) O94760-1 (A2-S285) ≥ 90%, as determined by reducing SDS-PAGE.

DDAH1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82916 DDAH1 Antibody (YA2661) WB, IP Human
HY-P82916A DDAH1 Antibody (YA2661)(PBS only) WB, IP Human

Related Diseases

Diseases Alias
Cardiovascular System Disease

  • Abnormality Of The Cardiovascular System

  • Cardiovascular Disease

  • Disease Of Subdivision Of Hemolymphoid System

  • Disorder Of Cardiovascular System

  • Cardiovascular Diseases
Pulmonary Hypertension

  • Primary Pulmonary Hypertension

  • Hypertension Pulmonary

  • Hypertension, Pulmonary

  • Hypertension, Pulmonary, Primary

  • Idiopathic Pulmonary Hypertension

  • Idiopathic Pulmonary Arterial Hypertension

  • Pulmonary Htn - [Hypertension]
Hypertension, Essential

  • Essential Hypertension

  • Hypertension

  • High Blood Pressure

  • Hypertension, Essential, Susceptibility To

  • Hypertensive Disease

  • Primary Hypertension

  • EHT

  • Hypertension, Salt-Sensitive Essential, Susceptibility To

  • Hyperpiesia

  • Idiopathic Hypertension

  • Hypertensive Disorder

  • Hypertension, Essential, Susceptibility To, 3

  • Hypertension, Essential 3

  • Hypertension, Essential, Salt-Sensitive

  • Hypertension, Essential, Susceptibility To, 6

  • Hypertension, Essential 6

  • Hypertension, Salt-Sensitive Essential

  • Hypertension, Susceptibility To

  • Hypertension, Essential, Susceptibility To, 4

  • Hypertension, Essential 4

  • Hypertension, Essential, Susceptibility To, 2

  • Hypertension, Essential 2

  • Hypertension, Essential, Susceptibility To, 1

  • Hypertension, Essential 1

  • Hypertension, Essential, Susceptibility To, 5

  • Hypertension, Essential 5

  • Htn

  • Vascular Hypertensive Disorder

  • Systemic Primary Arterial Hypertension

  • Hbp - [High Blood Pressure]

  • Systemic Arterial Hypertensive Disorder

  • Elevated Blood Pressure

  • Arterial Hypertension Nos

  • Hypertension Nos

  • Benign Hypertension

  • Systemic Arterial Hypertension

  • Systemic Hypertension

  • Artery Htn

  • Benign Htn

  • Vascular Htn

  • Vascular Hypertension

  • Cholesterol Hypertension

  • Cholesterol Htn

  • Idiopathic Htn

  • Malignant Hypertension

  • Malignant Htn

  • Raised Blood Pressure

  • Cardiovascular Hypertension

  • Primary Htn - [Hypertension]

  • High Arterial Tension

  • High Blood Pressure Disorder

  • Ht - [Hypertension]

  • Htn - [Hypertension]

  • Hypertensive Vascular Disease

  • Hypertensive Vascular Degeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16958 PD 404182 Inhibitor 98.26% Unkown
HY-RS03604 DDAH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19186 Ddah1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25674 Ddah1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DDAH1 MGD MGI:1916469
Felis catus DDAH1 VGNC VGNC:61384
Rattus norvegicus DDAH1 RGD RGD:70968
Bos taurus DDAH1 VGNC VGNC:27939
Macaca mulatta DDAH1 VGNC VGNC:71753
Canis familiaris DDAH1 VGNC VGNC:39827
Others DDAH1 NCBI