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PD 404182 

Cat. No.: HY-16958
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PD 404182 is a potent and competitive inhibitor of human dimethylarginine dimethylaminohydrolase 1 (DDAH1), with an IC50 of 9 μM. PD 404182 exhibits antiangiogenic and antiviral activity in vitro.

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PD 404182 Chemical Structure

PD 404182 Chemical Structure

CAS No. : 72596-74-8

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Description

PD 404182 is a potent and competitive inhibitor of human dimethylarginine dimethylaminohydrolase 1 (DDAH1), with an IC50 of 9 μM. PD 404182 exhibits antiangiogenic and antiviral activity in vitro[1][2].

IC50 & Target

IC50: 9 μM (DDAH1)[1]

In Vitro

PD 404182 (20 μM) increases asymmetric dimethylarginine (ADMA) approximately 70% in ECs[1].
PD 404182 (50-100 μM; 18 hours) attenuates endothelial tube formation in virto and does not perturb cell membrane integrity or induces cytotoxicity[1].
PD 404182 inhibits HIV-1 in seminal plasma, with an IC50 of 1 μM[2].
PD 404182 (300 μM;30 minutes) exhibits low toxicity toward several human cell lines , freshly activated PBMCs, primary CD4+ T lymphocytes, macrophages, and dendritic cells, and lactobacilli found in the normal vaginal flora[2].

Cell Viability Assay[1]

Cell Line: Human dermal microvascular endothelial cells (ECs)
Concentration: 10-300 μM
Incubation Time: 24 hours
Result: Did not induce cytotoxicity.
Molecular Weight

217.29

Formula

C₁₁H₁₁N₃S

CAS No.

72596-74-8

SMILES

N=C1SC2=CC=CC=C2C3=NCCCN13

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PD 404182PD404182PD-404182OthersDimethylargininedimethylaminohydrolaseDDAHantiangiogenicantiviralInhibitorinhibitorinhibit

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