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  3. Antibiotic
  4. PD 404182

PD 404182 

Cat. No.: HY-16958 Purity: 98.98%
COA Handling Instructions

PD 404182 is a potent and competitive inhibitor of human dimethylarginine dimethylaminohydrolase 1 (DDAH1), with an IC50 of 9 μM. PD 404182 exhibits antiangiogenic and antiviral activity in vitro.

For research use only. We do not sell to patients.

PD 404182 Chemical Structure

PD 404182 Chemical Structure

CAS No. : 72596-74-8

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 99 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
25 mg USD 280 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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1 Publications Citing Use of MCE PD 404182

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  • Customer Review

Description

PD 404182 is a potent and competitive inhibitor of human dimethylarginine dimethylaminohydrolase 1 (DDAH1), with an IC50 of 9 μM. PD 404182 exhibits antiangiogenic and antiviral activity in vitro[1][2].

IC50 & Target

IC50: 9 μM (DDAH1)[1]
In Vitro

PD 404182 (20 μM) increases asymmetric dimethylarginine (ADMA) approximately 70% in ECs[1].
PD 404182 (50-100 μM; 18 hours) attenuates endothelial tube formation in virto and does not perturb cell membrane integrity or induces cytotoxicity[1].
PD 404182 inhibits HIV-1 in seminal plasma, with an IC50 of 1 μM[2].
PD 404182 (300 μM;30 minutes) exhibits low toxicity toward several human cell lines , freshly activated PBMCs, primary CD4+ T lymphocytes, macrophages, and dendritic cells, and lactobacilli found in the normal vaginal flora[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Human dermal microvascular endothelial cells (ECs)
Concentration: 10-300 μM
Incubation Time: 24 hours
Result: Did not induce cytotoxicity.
Molecular Weight

217.29

Appearance

Solid

Formula

C11H11N3S
CAS No.
SMILES

N=C1SC2=CC=CC=C2C3=NCCCN13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (230.11 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6021 mL 23.0107 mL 46.0214 mL
5 mM 0.9204 mL 4.6021 mL 9.2043 mL
10 mM 0.4602 mL 2.3011 mL 4.6021 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (11.51 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (11.51 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (11.51 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.98%

COA (252 KB) HNMR (255 KB) LCMS (273 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PD 40418272596-74-8PD404182PD-404182AntibioticDimethylargininedimethylaminohydrolaseDDAHantiangiogenicantiviralInhibitorinhibitorinhibit

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