ENPP2 - ectonucleotide pyrophosphatase/phosphodiesterase 2 Gene

Also Known as ATX; NPP2; ATX-X; PDNP2; LysoPLD; AUTOTAXIN; PD-IALPHA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5168

About ENPP2

Cytogenetic location: 8q24.12 Genomic coordinates (GRCh38): 8:119,557,086-119,673,390 (from NCBI)

This gene has 9 transcripts (splice variants), 296 orthologues and 6 paralogues. Broad expression in placenta (RPKM 83.1), brain (RPKM 52.1) and 18 other tissues.

Summary

The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a Phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008]

ENPP2 Products (4)

mRNA	Protein	Name
NM_001040092.3	NP_001035181.1	ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 2 preproprotein
NM_001130863.3	NP_001124335.1	ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 3 preproprotein
NM_001330600.2	NP_001317529.1	ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 4
NM_006209.5	NP_006200.3	ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	26371182	GOA
enables lysophospholipase activity	IDA IDA: Inferred from direct assay	12354767	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	26371182	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in phosphatidylcholine catabolic process	IDA IDA: Inferred from direct assay	21240271	GOA
involved in phospholipid catabolic process	IDA IDA: Inferred from direct assay	15280042	GOA
involved in positive regulation of epithelial cell migration	IGI IGI: Inferred from genetic interaction	18054784	GOA
involved in positive regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	18054784	GOA
involved in positive regulation of lamellipodium morphogenesis	IGI IGI: Inferred from genetic interaction	18054784	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	18054784	GOA
involved in regulation of cell migration	IDA IDA: Inferred from direct assay	1733949	GOA
involved in sphingolipid catabolic process	IDA IDA: Inferred from direct assay	14500380	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	15280042	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENPP2 Protein Structure

Somatomedin_B

Phosphodiest

Endonuclease_NS

0
200
400
600
800
863 a.a.

Protein Preferred Names	Protein Names
ectonucleotide pyrophosphatase/phosphodiesterase family member 2	E-NPP 2

Recombinant ENPP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70167	ENPP-2 Protein, Human (HEK293, His)	AAH34961.1 (A36-I863)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Autoimmune Pancreatitis	Lymphoplasmocytic Sclerosing Pancreatitis Aip
Teratocarcinoma	Mixed Embryonal Carcinoma And Teratoma
Fibrosclerosis Of Breast	Fibrosis Of The Breast Breast Fibrosis
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Cholangitis	Acute Cholangiolitis Ascending Cholangitis Cholangiolitis Cholangitis Nos Chronic Cholangiolitis Hepatic Duct Inflammation Acute Cholangitis Bile Duct Inflammation
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Intrahepatic Cholestasis Of Pregnancy	Recurrent Intrahepatic Cholestasis Of Pregnancy Gravidic Intrahepatic Cholestasis Pregnancy-Related Cholestasis Icp Pregnancy Related Cholestasis Cholestasis, Intrahepatic Of Pregnancy Familial Intrahepatic Cholestasis Of Pregnancy Familial Recurrent Intrahepatic Cholestasis Of Pregnancy Ricp Obstetric Cholestasis
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Glaucoma, Primary Open Angle	Glaucoma 1, Open Angle, E Primary Open Angle Glaucoma POAG Adult-Onset Primary Open Angle Glaucoma Chronic Simple Glaucoma GLC1E Primary Open Angle Glaucoma 1e Glaucoma, Open Angle, Primary
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145344	ONO-8430506	Inhibitor	99.90%	Unkown
HY-143582	ATX inhibitor 9	Inhibitor	/	Unkown
HY-146124	ATX inhibitor 21	Inhibitor	/	Unkown
HY-175478	Enpp-1-IN-27		/	Unkown
HY-181667	Enpp-1-IN-30	Inhibitor	/	Unkown
HY-184200	Enpp-1-IN-32		/	Unkown
HY-RS04388	ENPP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17381	Enpp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23836	Enpp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ENPP2	VGNC	VGNC:28505
Canis familiaris	ENPP2	VGNC	VGNC:40375
Rattus norvegicus	ENPP2	RGD	RGD:69298
Felis catus	ENPP2	VGNC	VGNC:61873
Macaca mulatta	ENPP2	VGNC	VGNC:72223
Mus musculus	ENPP2	MGD	MGI:1321390
Others	ENPP2	NCBI