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KLC2 - kinesin light chain 2 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64837

About KLC2

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,243,938-66,267,860 (from NCBI)

This gene has 14 transcripts (splice variants), 183 orthologues, 5 paralogues and is associated with 2 phenotypes. Broad expression in brain (RPKM 19.0), testis (RPKM 14.0) and 23 other tissues.

Summary

The protein encoded by this gene is a light chain of Kinesin, a molecular motor responsible for moving vesicles and organelles along microtubules. Defects in this gene are a cause of spastic paraplegia, optic atrophy, and neuropathy (SPOAN) syndrome. [provided by RefSeq, Mar 2016]

KLC2 Products (5)

mRNA	Protein	Name
NM_001134774.2	NP_001128246.1	kinesin light chain 2 isoform 2
NM_001134775.2	NP_001128247.1	kinesin light chain 2 isoform 1
NM_001134776.2	NP_001128248.1	kinesin light chain 2 isoform 1
NM_001318734.2	NP_001305663.1	kinesin light chain 2 isoform 1
NM_022822.3	NP_073733.1	kinesin light chain 2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14985359	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in lysosome localization	IMP IMP: Inferred from mutant phenotype	22172677	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLC2 Protein Structure

Rab5-bind

TPR_2

TPR_12

TPR_10

0
100
200
300
400
500
622 a.a.

Protein Preferred Names	Protein Names
kinesin light chain 2	KLC 2

KLC2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KLC2	Q9H0B6	YWHAZ	Homo sapiens	P63104	CoIP	15324660
Intra	KLC2	Q9H0B6	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	KLC2	Q9H0B6	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	KLC2	Q9H0B6	SFN	Homo sapiens	P31947	TAP	15778465

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KLC2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76469	KLC2 Protein, Human (sf9, His-GST)	Q9H0B6-1 (M1-G622)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Spastic Paraplegia, Optic Atrophy, And Neuropathy	Spoan Syndrome SPOAN Spastic Paraplegia, Optic Atropy, And Neuropathy Spastic Paraplegia, Optic Atropy, And Neuropathy Syndrome Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome
Childhood Absence Epilepsy	Pyknolepsy Petit Mal Epilepsy Absence Seizures Absence Seizure Petit Mal Seizure Absence Epilepsy, Childhood Pykno-Epilepsy Epilepsy, Absence Absence Epilepsy Pycnolepsy
Specific Learning Disability	Specific Learning Difficulty Specific Learning Disorder
Aceruloplasminemia	Cerebellar Ataxia Hypoceruloplasminemia Hemosiderosis, Systemic, Due To Aceruloplasminemia Familial Apoceruloplasmin Deficiency Hereditary Ceruloplasmin Deficiency Deficiency Of Ferroxidase Hypoceruloplasminemia, Hereditary Ceruloplasmin Deficiency Systemic Hemosiderosis Due To Aceruloplasminemia ACERULOP
Paraplegia	Paraplegia, Lower Severe Or Complete Loss Of Motor Function In The Lower Extremities And Lower Portions Of The Trunk
Spinal Muscular Atrophy, Distal, Autosomal Recessive, 4	DSMA4 Autosomal Recessive Lower Motor Neuron Disease With Childhood Onset Distal Spinal Muscular Atrophy Type 4 Autosomal Recessive Distal Spinal Muscular Atrophy Type 4 Distal Spinal Muscular Atrophy, Autosomal Recessive, 4 Atrophy, Muscular, Spinal, Distal, Autosomal Recessive, Type 4
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112777	Kinesore		98.0%	Unkown
HY-RS07327	KLC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07328	KLC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20291	Klc2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26799	Klc2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KLC2	VGNC	VGNC:42427
Bos taurus	KLC2	VGNC	VGNC:30623
Mus musculus	KLC2	MGD	MGI:107953
Macaca mulatta	KLC2	VGNC	VGNC:73869
Felis catus	KLC2	VGNC	VGNC:63127
Rattus norvegicus	KLC2	RGD	RGD:1307377
Others	KLC2	NCBI