(Rac)-Atomoxetine hydrochloride
(Rac)-Atomoxetine hydrochloride ((Rac)-Tomoxetine (hydrochloride); (Rac)-LY 139603) is the racemic mixture of Atomoxetine hydrochloride (HY-17385). Atomoxetine hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride increases of DAEX and NEEX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research.
For research use only. We do not sell to patients.
- CAS No.: 82857-40-7
- Formula: C17H22ClNO
- Molecular Weight:291.82
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 82857-40-7
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Molecular Weight 291.82
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Formula C17H22ClNO
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SMILES
CC1=CC=CC=C1OC(CCNC)C2=CC=CC=C2.Cl
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Synonyms
(Rac)-Tomoxetine hydrochloride; (Rac)-LY 139603
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Turner M, et, al. Effects of atomoxetine on locomotor activity and impulsivity in the spontaneously hypertensive rat. Behav Brain Res. 2013 Apr 15;243:28-37. [Content Brief]
[2]. Föhr KJ, et, al. Block of Voltage-Gated Sodium Channels by Atomoxetine in a State- and Use-dependent Manner. Front Pharmacol. 2021 Feb 25;12:622489. [Content Brief]
[3]. Bymaster FP, et, al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 Nov;27(5):699-711. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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