country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-N19733

Copy Link Print Information

2′,3′-Dihydroxypuberulin

2′,3′-Dihydroxypuberulin is a naturally derived inhibitor of the FcεRI β-chain with FcεRI expression inhibitory activity in mast cells. 2′,3′-Dihydroxypuberulin suppresses the mRNA level of the FcεRI β-chain, blocks the assembly of the FcεRI tetramer, and reduces the cell surface expression level of FcεRI. 2′,3′-Dihydroxypuberulin can be used in studies related to type I allergic diseases.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 79147-77-6
화학식: C₁₆H₂₀O₇
분자량:324.33

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

2′,3′-Dihydroxypuberulin Chemical Structure

CAS No.: 79147-77-6

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

2′,3′-Dihydroxypuberulin (compound 1) (30 μg/mL; 72 h) inhibits FcεRI surface expression on HMC-1 human mast cells by 49.0%, and its absolute configuration does not affect this activity^[2].
2′,3′-Dihydroxypuberulin (50-100 μM; 36 h) significantly down-regulates FcεRI β-chain mRNA expression without altering α-chain or γ-chain mRNA levels in HMC-1 human mast cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[2]

Cell Line:

human mast cell line HMC-1
Concentration:

50, 100 μM
Incubation Time:

36 h
Result:

Suppressed FcεRI β-chain mRNA expression to ~85% of vehicle control levels, while α-chain and γ-chain mRNA levels remained near 95-98% of vehicle control (100 μM).
Suppressed FcεRI β-chain mRNA expression to ~60% of vehicle control, while α-chain and γ-chain mRNA levels remained near 90-95% of vehicle control (50 μM).

Chemical Information

CAS No. 79147-77-6
분자량 324.33
화학식 C₁₆H₂₀O₇
SMILES

COC1=C2C(C=CC(O2)=O)=CC(OC)=C1OCC(O)C(C)(O)C
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Magalhães AF, et al. Coumarins from Pterocaulon balansae and P. lanatum. Phytochemistry, 1981, 20(6):1369-1371.

[2]. Tamura S, et al. Inhibitor for FcεRI expression on mast cell from Verbasucum thapsus L. Bioorganic & medicinal chemistry letters. 2018 Nov 01;28(20):3342-3345. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기