ALK-IN-6
ALK-IN-6 (compound 11) is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK), with IC50 values of 71 nM, 18.72 nM and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L, respectively.
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- CAS No.: 2055821-33-3
- 화학식: C26H29D3ClN5O3S
- 분자량:533.10
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
IC50: 71 nM (ALK wild), 18.72 nM (ALK F1196M), 36.81 nM (ALK F1174L)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H2228 | IC50 |
41.3 nM
Compound: 11
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Growth inhibition of human NCI-H2228 cells
Growth inhibition of human NCI-H2228 cells
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[PMID: 31005443] |
| NCI-H3122 | IC50 |
4 nM
Compound: 11
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Growth inhibition of human NCI-H3122 cells
Growth inhibition of human NCI-H3122 cells
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[PMID: 31005443] |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2055821-33-3
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분자량 533.10
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화학식 C26H29D3ClN5O3S
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SMILES
ClC1=CN=C(NC2=C(OC([2H])([2H])[2H])C=C(C3CCNCC3)C(C)=C2)N=C1NC4=CC=CC=C4S(=O)(C(C)C)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ALK-IN-6 Related Classifications
HY-128596 Related Classifications
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