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Cat. No.: HY-183950

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ALK5-IN-87

ALK5-IN-87 is a potent lung-restricted ALK5 inhibitor with a pK_i of 10.13. ALK5-IN-87 exerts antifibrotic activity in a mouse model of lung fibrosis. ALK5-IN-87 can be used for the research of idiopathic pulmonary fibrosis.

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CAS No.: 2921605-02-7
화학식: C₂₅H₂₉ClFN₇O₂S
분자량:546.06

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

ALK5-IN-87 Chemical Structure

CAS No.: 2921605-02-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

ALK5-IN-87 (compound 20) inhibits TGF-β1-induced pSMAD2 phosphorylation in A549 cells with a pIC₅₀ of 7.28^[1].
ALK5-IN-87 inhibits TGF-β1-induced pSMAD2 phosphorylation in human lung fibroblasts with a pIC₅₀ of 7.69^[1].
ALK5-IN-87 potently inhibits purified ALK4 kinase domain with a pK_i of 9.86^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	CL_plasma	V_dss	T_1/2
Mice^[1]	2 mg/kg	i.v.	70 mL/min/kg	5.2 L/kg	1.7 h

In Vivo

ALK5-IN-87 (compound 20) (0.3-1 mg/kg; i.n.; once daily; starting at day 7 until day 21) exerts antifibrotic activity in a mouse model of lung fibrosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J mice (7-8 weeks old) with Bleomycin (BLM) (HY-17565)-induced lung fibrosis^[1]
Dosage:

0.3; 1 mg/kg
Administration:

i.n.; once daily; starting at day 7 until day 21
Result:

Significantly slowed down the decline in forced vital capacity (FVC) value by 43% at 1 mg/kg, ompared to BLM group.
Did not result in an increased efficacy compared to the lower dose of 1 mg/kg at 0.3 mg/kg.
Induced a significant decrease by 23% in the Ashcroft score compared to the vehicle/BLM-treated animals at 1 mg/kg.
Showed antifibrotic activity.

Chemical Information

CAS No. 2921605-02-7
분자량 546.06
화학식 C₂₅H₂₉ClFN₇O₂S
SMILES

O=C(NC1=NC=CC(NC2=CC(C3=CC(Cl)=CC=C3F)=NN=C2SCCO)=C1)CCN4CCN(C)CC4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Ronchi P, et al. Discovery of a Novel Lung-Restricted ALK5 Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis. J Med Chem. Published online May 18, 2026. [Content Brief]

Calculators

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Mass Mass

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Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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