Antibacterial agent 123
Antibacterial agent 123 (compound 111) is a potent membrane-disrupting agent to combat antibiotic-resistant Gram-positive bacteria.
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- CAS No.: 2615254-55-0
- 화학식: C17H8F9N3O
- 분자량:441.25
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Erythrocyte | CC50 |
>32 μg/mL
Compound: 111
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Cytotoxicity against sheep erythrocytes assessed as reduction in cell viability
Cytotoxicity against sheep erythrocytes assessed as reduction in cell viability
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[PMID: 36219779] |
Antibacterial agent 123 (compound 111) shows excellent activity (MIC<0.0625 μg/mL) toward S. aureus strains[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female CD-1 mice[1]
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Dosage:0.5 mg/kg, 10 mg/kg
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Administration:p.o. (10 mg/kg) and i.v. (0.5 mg/kg); once (Pharmacokinetic Analysis)
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Result:Pharmacokinetic Parameters of Antibacterial agent 123 in Female CD-1 Mice[1].
pharmacokinetic indices dose i.v., p.o. (mg/kg) AUC0-24 (i.v., h·ng/mL) Vd (i.v., mL/kg) CL (i.v., mL/(kg·h)) t1/2 (i.v., h) AUC0-24 (p.o., h·ng/mL) Cmax (p.o., ng/mL) F (%) compound 111 0.5, 10 (4.20 × 103) ± 308 322 ± 24 119 ± 9.2 1.88 ± 0.08 (4.33 × 104) ± 543 (3.10 × 103) ± 780 51.6 ± 5.2
Chemical Information
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CAS No. 2615254-55-0
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분자량 441.25
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화학식 C17H8F9N3O
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SMILES
O=C1C=C(C(F)(F)F)NC2=C1C(NC3=NC=C(C(F)(F)F)C=C3)=CC(C(F)(F)F)=C2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibacterial agent 123 Related Classifications
HY-151567 Related Classifications
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