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Cat. No.: HY-156468

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Antioxidant agent-17

Antioxidant agent-17 (compound 59) is a potent inhibitor of superoxide anion generation activity, with an IC₅₀ of 9.06 nM.

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화학식: C₂₀H₁₅FN₂O
분자량:318.34

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Antioxidant agent-17 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Antioxidant agent-17 (compound 59) is a potent inhibitor of superoxide anion generation activity, with an IC₅₀ of 9.06 nM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Neutrophil	IC₅₀	>10000 nM Compound: 59	Inhibition of fMLF/CB-induced human Neutrophil activation assessed as reduction in elastase release using MeO-Suc-Ala-Ala-Pro-Val-pnitroanilide as substrate incubated for 5 mins Inhibition of fMLF/CB-induced human Neutrophil activation assessed as reduction in elastase release using MeO-Suc-Ala-Ala-Pro-Val-pnitroanilide as substrate incubated for 5 mins	[PMID: 37918036]
Neutrophil	IC₅₀	9.06 nM Compound: 59	Inhibition of fMLF/CB-induced human Neutrophil activation assessed as reduction in superoxide anion generation preincubated with compound for 2 mins prior to CB induction for 3 mins followed by fMLF addition by spectrophotometric analysis Inhibition of fMLF/CB-induced human Neutrophil activation assessed as reduction in superoxide anion generation preincubated with compound for 2 mins prior to CB induction for 3 mins followed by fMLF addition by spectrophotometric analysis	[PMID: 37918036]

In Vivo

The half-life of Antioxidant agent-17 (compound 59) is approximately 79 min when using intravenous bolus administration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 318.34
화학식 C₂₀H₁₅FN₂O
SMILES

FC1=CC=CC=C1CN2N=C(C3=CC=CO3)C=C2C4=CC=CC=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yu KH, et al. Design and synthesis of pyrazole derivatives against neutrophilic inflammation. Eur J Med Chem. 2023 Oct 26;262:115874. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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