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Cat. No.: HY-185463

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β-Tryptase-IN-1

β-Tryptase-IN-1 is a selective β-tryptase inhibitor with a K_i of 10 nM. β-Tryptase-IN-1 binds to the inducible S4⁺ pocket unique to β-tryptase. β-Tryptase-IN-1 can be used for the researches of asthma and chronic obstructive pulmonary disease (COPD).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 725228-46-6
화학식: C₂₇H₂₄F₄N₂O₄
분자량:516.48

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

β-Tryptase-IN-1 Chemical Structure

CAS No.: 725228-46-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- Parmacokinetics
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

β-Tryptase-IN-1 (Compound 2) (0.0046-10 μM; 30 min) potently inhibits human recombinant β-tryptase with a K_i of 10 nM^[1].
β-Tryptase-IN-1 shows exquisite selectivity, with no detectable inhibition (IC₅₀ >100 μM) against factor Xa, thrombin, trypsin, elastase, or chymase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	T_max	Bioavailability	CL	T_1/2	V_ss
Rat^[1]	2 mg/kg	i.v.	/	/	/	8.4 L/h/kg	2.2 h	18.5 L/kg
Rat^[1]	10 mg/kg	p.o.	121 ng/mL	3.7 h	77 %	/	/	/

Chemical Information

CAS No. 725228-46-6
분자량 516.48
화학식 C₂₇H₂₄F₄N₂O₄
SMILES

O=C(C(F)(F)F)O.O=C(N1CCC(CC1)C2=CC(CN)=CC=C2)C3=CC=C(C#CC4=C(F)C=CC=C4)O3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Liang G, et al. Structure-based library design and the discovery of a potent and selective mast cell β-tryptase inhibitor as an oral therapeutic agent. Bioorg Med Chem Lett. 2012;22(2):1049-1054. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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