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Cat. No.: HY-147692

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COX-2-IN-14

COX-2-IN-14 (compound 2a) is a potent and selective COX-2 (cyclooxygenase-2) inhibitor. COX-2-IN-14 shows effective binding at the active site of COX-2 co-crystal. COX-2-IN-14 exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity in mice.

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CAS No.: 2428387-48-6
화학식: C₁₈H₁₈N₄O₆
분자량:386.36

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

COX-2-IN-14 Chemical Structure

CAS No.: 2428387-48-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

COX-2

All COX Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
J774.A1	CC₅₀	<100 μM Compound: 2a	Cytotoxicity against mouse J774A1 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Cytotoxicity against mouse J774A1 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 32503692]
L929	CC₅₀	257.42 μM Compound: 2a	Cytotoxicity against mouse L929 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against mouse L929 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 32503692]

Chemical Information

CAS No. 2428387-48-6
분자량 386.36
화학식 C₁₈H₁₈N₄O₆
SMILES

CCOC(C1=C(C=C(C([O-])=N1)C#N)C(C2=CC=C(C=C2)[N+]([O-])=O)=O)=O.C[NH2+]C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gonçalves DS, et al. Synthesis of novel 3,5,6-trisubstituted 2-pyridone derivatives and evaluation for their anti-inflammatory activity. Bioorg Med Chem. 2020 Jun 15;28(12):115549. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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COX-2-IN-14

All COX Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

COX-2-IN-14 Related Classifications

HY-147692 Related Classifications