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Cat. No.: HY-150551

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COX-2-IN-27

COX-2-IN-27 is a potent and selective COX-2 inhibitor with IC₅₀ values of 13.22, 0.045, 1.67 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-27 shows anti-inflammatory activity.

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CAS No.: 2413565-17-8
화학식: C₂₉H₂₄ClN₇S₃
분자량:602.20

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

COX-2-IN-27 Chemical Structure

CAS No.: 2413565-17-8

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수량

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

COX-2-IN-27 is a potent and selective COX-2 inhibitor with IC₅₀ values of 13.22, 0.045, 1.67 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-27 shows anti-inflammatory activity^[1].

IC₅₀ & Target^[1]

COX-1

13.22 μM (IC₅₀)

COX-2

0.045 μM (IC₅₀)

15-LOX

1.67 μM (IC₅₀)

All COX Isoforms :

In Vitro

COX-2-IN-27 (compound 15b) shows significant COX-2 selectivity with an SI value of 293.78^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

COX-2-IN-27 (28 µM/kg) shows a potent anti-inflammatory activity in rats with edema inhibition relative to indomethacin of 93.20% and 109.08% in 4h and 3h, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2413565-17-8
분자량 602.20
화학식 C₂₉H₂₄ClN₇S₃
SMILES

CSC1=NC2=CC=CC=C2N1C3=CSC(NC/C(C)=N/N=C4SC=C(C5=CC=C(Cl)C=C5)N\4C6=CC=CC=C6)=N3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28(7):115403. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
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수량:
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COX-2-IN-27

All COX Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

COX-2-IN-27 Related Classifications

HY-150551 Related Classifications