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United States

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Cat. No.: HY-184710

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COX-2-IN-69

COX-2-IN-69 is a selective, orally active COX-2 inhibitor with an IC₅₀ of 0.90 μM. COX-2-IN-69 occupies the secondary pocket of COX-2, interacts with His90 and Arg513, and reduces serum levels of PGE₂, IL-1β and TNF-α. COX-2-IN-69 exerts anti-inflammatory activity in a rat paw swelling model. COX-2-IN-69 can be used in inflammation-related research.

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화학식: C₂₁H₁₉BrN₂O
분자량:395.29

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

COX-2-IN-69 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

In Vivo

COX-2-IN-69 (Compound 4c) (10 mg/kg; p.o.; single administration) exhibits potent in vivo anti-inflammatory activity in a rat paw edema model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague Dawley (male, 130-150 g, Carrageenan (HY-125474)-induced paw edema model)^[1]
Dosage:

10 mg/kg
Administration:

p.o.; single dose
Result:

Reduced paw edema percentage to 9.91% at 3 hours post-Carrageenan injection.
Showed no significant difference in paw volume compared to normal control at 2 and 3 hours.
Reduced serum PGE2 levels by 59.37%, serum IL-1β levels by 57.81%, and serum TNF-α levels by 54.70% compared to the Carrageenan control group.
Caused moderate desquamation of gastric mucosa, inflammatory cell infiltration of the submucosa layer, and vacuolar degeneration of gastric glands.

Chemical Information

분자량 395.29
화학식 C₂₁H₁₉BrN₂O
SMILES

BrC(C=C1)=CC=C1CC2=CC(/C=C/C3=C(C)C=C(C)C=C3)=NNC2=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Elbahrawy AH, et al. Design, synthesis, biological evaluation and histopathological studies of Pyridazine and Pyrazoline derivatives as potential anti-inflammatory agents. Bioorganic chemistry. 2026 Jun 24;180:110164. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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