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Cat. No.: HY-149251

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DENV-IN-10

DENV-IN-10 is a potent tetravalent dengue inhibitor, with EC₅₀s of 1.36, 0.87, 0.94, and 0.95 μM against DENV-1-4 serotypes, respectively. DENV-IN-10 is a post-entry replication inhibitor that appears to be specific for cells of primate origin.

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CAS No.: 3043724-36-0
화학식: C₂₆H₂₅N₃O₄S
분자량:475.56

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

DENV-IN-10 Chemical Structure

CAS No.: 3043724-36-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	>100 μM Compound: 26	Cytotoxicity against human A549 cells Cytotoxicity against human A549 cells	[PMID: 36965228]
BHK-21	CC₅₀	>25 μM Compound: 26	Cytotoxicity against hamster BHK-21 cells Cytotoxicity against hamster BHK-21 cells	[PMID: 36965228]
Calu-1	CC₅₀	>100 μM Compound: 26	Cytotoxicity against human Calu-1 cells Cytotoxicity against human Calu-1 cells	[PMID: 36965228]
Huh-7	CC₅₀	>100 μM Compound: 26	Cytotoxicity against human Huh-7 cells Cytotoxicity against human Huh-7 cells	[PMID: 36965228]
Huh-7	CC₅₀	>100 μM Compound: 26	Cytotoxicity against human Huh-7 cells treated for 48 hrs measured by celltitre-glo luminescent assay Cytotoxicity against human Huh-7 cells treated for 48 hrs measured by celltitre-glo luminescent assay	[PMID: 36965228]
Vero	CC₅₀	>25 μM Compound: 26	Cytotoxicity against green monkey Vero cells Cytotoxicity against green monkey Vero cells	[PMID: 36965228]

In Vitro

DENV-IN-10 (compound 26) (10 μM; added either prior to DENV infection, during infection (0 h) or at different time points post-infection (2, 6, 12, 24 hpi)) exhibits no significant antiviral activity after pre- and co-treatment and reduces the level of infectious viral particles at 2 h post-infection and remained effective even when added at 24 h post-infection^[1].
DENV-IN-10 (10 μM; 24-60 h) reduces the viral RNA copy numbers and the expression of viral proteins NS3 and NS5 in Huh-7 cells infected with DENV-2^[1].
DENV-IN-10 (0.1-20 μM) significantly inhibits DENV-2 replication in primate cell lines but EC₅₀s are higher in mosquito cells and baby hamster kidney cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3043724-36-0
분자량 475.56
화학식 C₂₆H₂₅N₃O₄S
SMILES

CCCOC1=CC=C(C(C(NCC2=CC=CC=C2)=O)=C1)NS(=O)(C3=CC=CC4=C3N=CC=C4)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Felicetti T, et, al. Functionalized sulfonyl anthranilic acid derivatives inhibit replication of all the four dengue serotypes. Eur J Med Chem. 2023 Apr 5;252:115283. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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