E/Z-FETPY
E/Z-FETPY is an organo-diiron(I) complex with strong cytotoxicity in cancer cell lines. E/Z-FETPY induces ferroptosis in low-differentiated cell lines, such as A2780 cells.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 3056250-97-3
- 화학식: C22H24F3Fe2N2O5S2
- 분자량:629.25
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
E/Z-FETPY (72 h) shows cytotoxic potential that inhibits the growth of HCT 116, MCF7, and A2780 cells with IC50 values 4 μM, 2.1 μM, and 2.5 μM, respectively[1].
E/Z-FETPY (2.5 μM; 24-48 h) shows a time-dependent increase in iron uptake was detected upon incubation of A2780 cells. E/Z-FETPY suppresses hydrogen peroxide (H2O2) and peroxynitrite (O═NOO-) along with amplified production of superoxide anion (O2-) and nitric oxide (NO)[1].
FETPY (5 μM) induces significant morphological changes in murine B16-F1 and B16-F10 melanoma cells, leading to senescence and/or trans-differentiation into Schwann-like cells, thus significantly reducing their tumorigenic potential[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:8-12 weeks old C57BL/6 male or female mice injected with B16-F1 or B16-F10 cells[1]
-
Dosage:4 mg/kg
-
Administration:i.p.; once a day; for 3 weeks
-
Result:Suppressed tumor growth in low- and high-grade syngeneic melanoma models.
Chemical Information
-
CAS No. 3056250-97-3
-
분자량 629.25
-
화학식 C22H24F3Fe2N2O5S2
-
SMILES
FC(F)(S(=O)([O-])=O)F.C[s]c1[Fe]2([N]3=CC=C(N(C)C)C=C3)([])[Fe-]1([])([CH+]#O)C2=O.[+].C4CCCC4.C5CCCC5
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
E/Z-FETPY Related Classifications
HY-158336 Related Classifications
Powered by Bioz