Formamide-13C
Based on 1 Customer Validation
Formamide-13C is the 13C-labeled Formamide (HY-Y0842). Formamide is an effective DNA denaturant that significantly reduces the stability of DNA in buffer solutions. Formamide can also be used as a decalcifying agent for rat cardiac cells. Additionally, formamide is widely used as a solvent or chemical raw material for ion compounds, resins, and plasticizers.
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- Purity: 99.9%
- CAS No.: 51284-91-4
- 화학식: 13CH3NO
- 분자량:46.03
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보관:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 51284-91-4
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Unlabeled Cas 75-12-7
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Appearance Liquid (Density: 0.978±0.06 g/cm3)
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분자량 46.03
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화학식 13CH3NO
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Color Colorless to light yellow
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SMILES
N[13CH]=O
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Synonyms
Methanamide-13C; Formimidic acid-13C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 100 mg/mL (2172.50 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
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Handling Instructions (2659 KB)
References
[1]. Kamineni VK, et al. Layer-by-layer nanoassembly of polyelectrolytes using formamide as the working medium. Langmuir. 2007;23(14):7423-7. [Content Brief]
[2]. Blake RD, et al. Thermodynamic effects of formamide on DNA stability. Nucleic Acids Res. 1996 Jun 1;24(11):2095-103. [Content Brief]
[3]. Costanzo G, et al. Formamide as the main building block in the origin of nucleic acids. BMC Evol Biol. 2007 Aug 16;7 Suppl 2(Suppl 2):S1. [Content Brief]
[4]. Brette F, et al. Validation of formamide as a detubulation agent in isolated rat cardiac cells. Am J Physiol Heart Circ Physiol. 2002 Oct;283(4):H1720-8. [Content Brief]
[5]. Frankfurt OS, Krishan A. Identification of apoptotic cells by formamide-induced dna denaturation in condensed chromatin. J Histochem Cytochem. 2001 Mar;49(3):369-78. [Content Brief]
[6]. Messier PE.Messier PE. Effects of formamide on neuroepithelial cells and on interkinetic nuclear migration in the chick embryo. J Embryol Exp Morphol. 1976 Feb;35(1):197-212. [Content Brief]
[7]. National Toxicology Program. Toxicology and carcinogenesis studies of formamide (Cas No. 75-12-7) in F344/N rats and B6C3F1 mice (gavage studies). Natl Toxicol Program Tech Rep Ser. 2008 Jul;(541):1-192. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 21.7250 mL | 108.6248 mL | 217.2496 mL | 543.1241 mL |
| 5 mM | 4.3450 mL | 21.7250 mL | 43.4499 mL | 108.6248 mL | |
| 10 mM | 2.1725 mL | 10.8625 mL | 21.7250 mL | 54.3124 mL | |
| 15 mM | 1.4483 mL | 7.2417 mL | 14.4833 mL | 36.2083 mL | |
| 20 mM | 1.0862 mL | 5.4312 mL | 10.8625 mL | 27.1562 mL | |
| 25 mM | 0.8690 mL | 4.3450 mL | 8.6900 mL | 21.7250 mL | |
| 30 mM | 0.7242 mL | 3.6208 mL | 7.2417 mL | 18.1041 mL | |
| 40 mM | 0.5431 mL | 2.7156 mL | 5.4312 mL | 13.5781 mL | |
| 50 mM | 0.4345 mL | 2.1725 mL | 4.3450 mL | 10.8625 mL | |
| 60 mM | 0.3621 mL | 1.8104 mL | 3.6208 mL | 9.0521 mL | |
| 80 mM | 0.2716 mL | 1.3578 mL | 2.7156 mL | 6.7891 mL | |
| 100 mM | 0.2172 mL | 1.0862 mL | 2.1725 mL | 5.4312 mL |
Formamide-13C Related Classifications
HY-Y0842S Related Classifications
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