Cnih2 - cornichon family AMPA receptor auxiliary protein 2 Gene

Also Known as Cnih3; CNIH-2; RGD1304930

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 361705

Summary

Involved in negative regulation of anterograde synaptic vesicle transport; negative regulation of receptor localization to synapse; and regulation of neurotransmitter receptor activity. Acts upstream of or within glutamatergic synaptic transmission; localization within membrane; and regulation of membrane potential. Located in dendritic shaft and postsynaptic membrane. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Orthologous to human CNIH2 (cornichon family AMPA Receptor auxiliary protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Cnih2 Products (1)

mRNA Protein Name
NM_001025132.1 NP_001020303.1 protein cornichon homolog 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20805473 RGD
Biological Process GO Annotation Evidence References Source
acts upstream of or within localization within membrane IDA
IDA: Inferred from direct assay
19265014 RGD
involved in negative regulation of anterograde synaptic vesicle transport IMP
IMP: Inferred from mutant phenotype
24094107 RGD
involved in negative regulation of receptor localization to synapse IMP
IMP: Inferred from mutant phenotype
24094107 RGD
involved in regulation of AMPA receptor activity IDA
IDA: Inferred from direct assay
19265014 RGD
involved in regulation of AMPA receptor activity IMP
IMP: Inferred from mutant phenotype
24094107 RGD
involved in regulation of NMDA receptor activity IMP
IMP: Inferred from mutant phenotype
24094107 RGD
acts upstream of or within regulation of membrane potential IDA
IDA: Inferred from direct assay
19265014 RGD
acts upstream of or within synaptic transmission, glutamatergic IDA
IDA: Inferred from direct assay
19265014 RGD
Cellular Component GO Annotation Evidence References Source
part of AMPA glutamate receptor complex IDA
IDA: Inferred from direct assay
19265014 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
19265014 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21172611 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
24853943 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
21172611 RGD
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
19265014 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein cornichon homolog 2

  • cornichon homolog 2

  • cornichon homolog 3

  • cornichon-like protein

Cnih2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Cnih2 Q5BJU5 Gria1 Rattus norvegicus P19490
Anti Bait CoIP
20805473
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS02885 CNIH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20890 Cnih2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27407 Cnih2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cnih2 NCBI NCBI:254263