AIFM2 - apoptosis inducing factor mitochondria associated 2 Gene

Also Known as AMID; FSP1; PRG3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84883

About AIFM2

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:70,112,271-70,132,825 (from NCBI)

This gene has 4 transcripts (splice variants) and 204 orthologues. Broad expression in fat (RPKM 26.6), thyroid (RPKM 7.3) and 22 other tissues.

Summary

This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to Apoptosis in the presence of Bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon Cancer cells. [provided by RefSeq, Nov 2010]

AIFM2 Products (2)

mRNA Protein Name
NM_001198696.2 NP_001185625.1 ferroptosis suppressor protein 1
NM_032797.6 NP_116186.1 ferroptosis suppressor protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
15958387 GOA
enables electron-transferring-flavoprotein dehydrogenase activity IDA
IDA: Inferred from direct assay
15958387 GOA
enables flavin adenine dinucleotide binding IDA
IDA: Inferred from direct assay
15958387 GOA
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA
IDA: Inferred from direct assay
31634899 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within apoptotic mitochondrial changes IDA
IDA: Inferred from direct assay
11980907 GOA
involved in cellular detoxification IDA
IDA: Inferred from direct assay
35922516 GOA
involved in negative regulation of ferroptosis IDA
IDA: Inferred from direct assay
35922516 GOA
involved in negative regulation of ferroptosis IMP
IMP: Inferred from mutant phenotype
31634899 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
11980907 GOA
involved in ubiquinone metabolic process IDA
IDA: Inferred from direct assay
31634899 GOA
involved in vitamin K metabolic process IDA
IDA: Inferred from direct assay
35922516 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12135761 GOA
located in cytosol IDA
IDA: Inferred from direct assay
11980907 GOA
located in lipid droplet IDA
IDA: Inferred from direct assay
14741744 GOA
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
11980907 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
11980907 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
31634900 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AIFM2 Protein Structure

Pyr_redox_2

Pyr_redox_2: Pyridine nucleotide-disulphide oxidoreductase (13 - 289)

Pyr_redox

Pyr_redox: Pyridine nucleotide-disulphide oxidoreductase (145 - 213)

  • 0
  • 100
  • 200
  • 300
  • 373 a.a.
Protein Preferred Names Protein Names

ferroptosis suppressor protein 1

  • apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death

AIFM2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AIFM2 Q9BRQ8 TRIM69 Homo sapiens Q86WT6-2
Y2H Prey Pooling
32296183
Intra
AIFM2 Q9BRQ8 TRIM69 Homo sapiens Q86WT6-2
Y2H Array
32296183
Intra
AIFM2 Q9BRQ8 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
32296183
Intra
AIFM2 Q9BRQ8 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra
AIFM2 Q9BRQ8 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra
AIFM2 Q9BRQ8 CNPY4 Homo sapiens Q8N129
Y2H Array
32296183
Intra
AIFM2 Q9BRQ8 CNPY4 Homo sapiens Q8N129
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

AIFM2 Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P80679 AMID/FSP1 Antibody WB, IHC-P, ICC/IF, ELISA Human, Mouse, Monkey

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-136057 iFSP1 Activator 99.96% Unkown
HY-RS00493 AIFM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-157744 Coumarin–quinone conjugate 99.9% Unkown
HY-RS17756 Aifm2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24223 Aifm2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris AIFM2 VGNC VGNC:37738
Rattus norvegicus AIFM2 RGD RGD:1304964
Macaca mulatta AIFM2 VGNC VGNC:69666
Mus musculus AIFM2 MGD MGI:1918611
Bos taurus AIFM2 VGNC VGNC:25762
Felis catus AIFM2 VGNC VGNC:59700
Others AIFM2 NCBI