2. Gene
  3. AIFM2 - apoptosis inducing factor mitochondria associated 2 Gene

AIFM2 - apoptosis inducing factor mitochondria associated 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as AMID; FSP1; PRG3

Gene ID: 84883 | Gene type: protein coding

About AIFM2

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:70,112,271-70,132,825 (from NCBI)

This gene has 4 transcripts (splice variants) and 204 orthologues. Broad expression in fat (RPKM 26.6), thyroid (RPKM 7.3) and 22 other tissues.

Summary

This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to Apoptosis in the presence of Bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon Cancer cells. [provided by RefSeq, Nov 2010]

AIFM2 Products(2)

mRNA Protein Name
NM_001198696.2 NP_001185625.1 ferroptosis suppressor protein 1
NM_032797.6 NP_116186.1 ferroptosis suppressor protein 1

AIFM2 Protein Structure

Pyr_redox_2

Pyr_redox_2: Pyridine nucleotide-disulphide oxidoreductase (13 - 289)

Pyr_redox

Pyr_redox: Pyridine nucleotide-disulphide oxidoreductase (145 - 213)

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  • 373 a.a.
Protein Preferred Names Protein Names

ferroptosis suppressor protein 1

apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136057 iFSP1 Activator 99.89% Unkown
HY-RS00493 AIFM2 Human Pre-designed siRNA Set A / Unkown
HY-157744 Coumarin–quinone conjugate / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris AIFM2 VGNC VGNC:37738
Rattus norvegicus AIFM2 RGD RGD:1304964
Macaca mulatta AIFM2 VGNC VGNC:69666
Mus musculus AIFM2 MGD MGI:1918611
Bos taurus AIFM2 VGNC VGNC:25762
Felis catus AIFM2 VGNC VGNC:59700