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Cat. No.: HY-185450

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GlcB-IN-1

GlcB-IN-1 is an inhibitor of Mycobacterium malate synthase (GlcB) with an IC₅₀ of 1.05 μM. GlcB-IN-1 can be used for the research of tuberculosis.

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CAS No.: 1346745-52-5
화학식: C₁₂H₉NO₄
분자량:231.20

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

GlcB-IN-1 Chemical Structure

CAS No.: 1346745-52-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
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Biological Activity

제품 설명

GlcB-IN-1 is an inhibitor of Mycobacterium malate synthase (GlcB) with an IC₅₀ of 1.05 μM. GlcB-IN-1 can be used for the research of tuberculosis^[1].

In Vitro

GlcB-IN-1 (compound 19) binds to malate synthase (GlcB) from Mycobacterium tuberculosis, and the resulting complex retains the closed active site lid and the "inward" conformation of the CoA-binding loop, forming a weak hydrogen bond with Met-631^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1346745-52-5
분자량 231.20
화학식 C₁₂H₉NO₄
SMILES

O=C(/C=C(C(O)=O)\O)C1=CNC2=CC=CC=C21
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Huang HL, et al. Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. J Biol Chem. 2016;291(53):27421-27432. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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