Guaifenesin-d3
Based on 1 Customer Validation
Guaifenesin-d3 is the deuterium labeled Guaifenesin. Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.00%
- CAS No.: 1189924-85-3
- 화학식: C10H11D3O4
- 분자량:201.23
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1189924-85-3
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Unlabeled Cas 93-14-1
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Appearance Solid
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분자량 201.23
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화학식 C10H11D3O4
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Color White to off-white
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SMILES
OCC(O)COC1=C(C=CC=C1)OC([2H])([2H])[2H]
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Synonyms
Guaiacol glyceryl ether-d3; Guaiphenesin-d3; Glycerol guaiacolate-d3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : ≥ 30 mg/mL (149.08 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
DMF : ≥ 30 mg/mL (149.08 mM)
Ethanol : ≥ 15 mg/mL (74.54 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Bennett, S., N. Hoffman, and M. Monga, Ephedrine- and guaifenesin-induced nephrolithiasis. J Altern Complement Med, 2004. 10(6): p. 967-9. [Content Brief]
[3]. Dicpinigaitis PV, et, al. Effect of guaifenesin on cough reflex sensitivity. Chest. 2003 Dec;124(6):2178-81. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO / DMF | 1 mM | 4.9694 mL | 24.8472 mL | 49.6944 mL | 124.2360 mL |
| 5 mM | 0.9939 mL | 4.9694 mL | 9.9389 mL | 24.8472 mL | |
| 10 mM | 0.4969 mL | 2.4847 mL | 4.9694 mL | 12.4236 mL | |
| 15 mM | 0.3313 mL | 1.6565 mL | 3.3130 mL | 8.2824 mL | |
| 20 mM | 0.2485 mL | 1.2424 mL | 2.4847 mL | 6.2118 mL | |
| 25 mM | 0.1988 mL | 0.9939 mL | 1.9878 mL | 4.9694 mL | |
| 30 mM | 0.1656 mL | 0.8282 mL | 1.6565 mL | 4.1412 mL | |
| 40 mM | 0.1242 mL | 0.6212 mL | 1.2424 mL | 3.1059 mL | |
| 50 mM | 0.0994 mL | 0.4969 mL | 0.9939 mL | 2.4847 mL | |
| 60 mM | 0.0828 mL | 0.4141 mL | 0.8282 mL | 2.0706 mL | |
| DMSO / DMF | 80 mM | 0.0621 mL | 0.3106 mL | 0.6212 mL | 1.5529 mL |
| 100 mM | 0.0497 mL | 0.2485 mL | 0.4969 mL | 1.2424 mL |
Guaifenesin-d3 Related Classifications
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