HDAC8-IN-11

ADC Targets in Oncology

2026-04-10

Cell Line	Type	Value	Description	References
A549	IC₅₀	>33.3 μM Compound: 6	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay	[PMID: 39089850]
A549	IC₅₀	>33.3 μM Compound: 6	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs in presence of tert-butyl 2-(4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidin-1-yl)acetate by MTS assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs in presence of tert-butyl 2-(4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidin-1-yl)acetate by MTS assay	[PMID: 39089850]
HCT-116	IC₅₀	>33.3 μM Compound: 6	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay	[PMID: 39089850]
HCT-116	IC₅₀	>33.3 μM Compound: 6	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs in presence of tert-butyl 2-(4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidin-1-yl)acetate by MTS assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs in presence of tert-butyl 2-(4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidin-1-yl)acetate by MTS assay	[PMID: 39089850]
Jurkat	IC₅₀	>33.3 μM Compound: 6	Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay	[PMID: 39089850]
Jurkat	IC₅₀	>33.3 μM Compound: 6	Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs in presence of tert-butyl 2-(4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidin-1-yl)acetate by MTS assay Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs in presence of tert-butyl 2-(4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidin-1-yl)acetate by MTS assay	[PMID: 39089850]
THP-1	IC₅₀	>33.3 μM Compound: 6	Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay	[PMID: 39089850]
THP-1	IC₅₀	>33.3 μM Compound: 6	Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 72 hrs in presence of tert-butyl 2-(4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidin-1-yl)acetate by MTS assay Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 72 hrs in presence of tert-butyl 2-(4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidin-1-yl)acetate by MTS assay	[PMID: 39089850]

Cell Line

Type

Value

Description

References

A549

IC₅₀

>33.3 μM

Compound: 6

Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay

[PMID: 39089850]

A549

IC₅₀

>33.3 μM

Compound: 6

Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs in presence of tert-butyl 2-(4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidin-1-yl)acetate by MTS assay

[PMID: 39089850]

HCT-116

IC₅₀

>33.3 μM

Compound: 6

Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay

[PMID: 39089850]

HCT-116

IC₅₀

>33.3 μM

Compound: 6

Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs in presence of tert-butyl 2-(4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidin-1-yl)acetate by MTS assay

[PMID: 39089850]

Jurkat

IC₅₀

>33.3 μM

Compound: 6

Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay

[PMID: 39089850]

Jurkat

IC₅₀

>33.3 μM

Compound: 6

Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs in presence of tert-butyl 2-(4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidin-1-yl)acetate by MTS assay

[PMID: 39089850]

THP-1

IC₅₀

>33.3 μM

Compound: 6

Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay

[PMID: 39089850]

THP-1

IC₅₀

>33.3 μM

Compound: 6

Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 72 hrs in presence of tert-butyl 2-(4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidin-1-yl)acetate by MTS assay

[PMID: 39089850]

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