Iptriazopyrid
Based on 1 Customer Validation
Iptriazopyrid is a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor, with a Ki value of 24.3 nM against Arabidopsis thaliana and 33.3 nM against Oryza sativa. Iptriazopyrid binds to the active pocket of HPPD, occupies the catalytic site, inhibits carotenoid biosynthesis, prevents chloroplast formation, and induces albino and chlorotic symptoms in sensitive plants. Used as a herbicide, Iptriazopyrid can control barnyardgrass when applied alone, and its efficacy does not decrease when mixed with labeled residual herbicides. When Iptriazopyrid is mixed with 2,4-D or triclopyr, its barnyardgrass control effect shows an antagonistic effect. Iptriazopyrid is a triazole carboxamide herbicide that exhibits selectivity for Oryza sativa over Echinochloa crus-galli, and has partial tank-mix compatibility with synthetic auxin herbicides registered for rice.
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- Purity: 99.86%
- CAS No.: 1994348-72-9
- 화학식: C15H15F3N6O4S
- 분자량:432.38
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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HPPD 24.3 |
HPPD 33.3 nM (Ki) |
Iptriazopyrid (0.1-10 μM; 7 days) potently induces chlorosis and inhibits growth in Echinochloa crus-galli with an IC50 of 6.3 g ai ha−1, demonstrating greater phytotoxicity than Mesotrione (HY-12853)[1].
Iptriazopyrid (0.1-10 μM; 7 days) has its phytotoxic effects in Echinochloa crus-galli reversed by Homogentisic acid (HY-113283), confirming iptriazopyrid acts by inhibiting the 4-hydroxyphenylpyruvate dioxygenase pathway[1].
Iptriazopyrid (1000 ng total per plant; 6-48 h) is rapidly metabolized by Oryza sativa into the non-phytotoxic metabolite 656Ox-1, resulting in lower internal iptriazopyrid levels compared to Echinochloa crus-galli, which underlies the compound's selectivity for rice[1].
Iptriazopyrid (2 mM; 1-5 weeks) binds to the catalytic active pocket of both Arabidopsis thaliana HPPD and Oryza sativa HPPD via conserved coordination and hydrophobic interactions, acting as a slow-binding inhibitor of the enzyme[1].
Iptriazopyrid (200-500 nM for AtHPPD; 200-800 nM for OsHPPD; 25 min) potently inhibits Arabidopsis thaliana HPPD with a Ki of 24.3 nM and Oryza sativa HPPD with a Ki of 33.3 nM, showing comparable slow-binding inhibitory activity to Mesotrione[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1994348-72-9
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Appearance Solid
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분자량 432.38
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화학식 C15H15F3N6O4S
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Color White to light yellow
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SMILES
CC1=NN=C(O1)NC(C2=CC=C(N3C(CS(=O)(C(C)C)=O)=NN=C23)C(F)(F)F)=O
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Synonyms
NC-656
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 100 mg/mL (231.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (278 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3128 mL | 11.5639 mL | 23.1278 mL | 57.8195 mL |
| 5 mM | 0.4626 mL | 2.3128 mL | 4.6256 mL | 11.5639 mL | |
| 10 mM | 0.2313 mL | 1.1564 mL | 2.3128 mL | 5.7820 mL | |
| 15 mM | 0.1542 mL | 0.7709 mL | 1.5419 mL | 3.8546 mL | |
| 20 mM | 0.1156 mL | 0.5782 mL | 1.1564 mL | 2.8910 mL | |
| 25 mM | 0.0925 mL | 0.4626 mL | 0.9251 mL | 2.3128 mL | |
| 30 mM | 0.0771 mL | 0.3855 mL | 0.7709 mL | 1.9273 mL | |
| 40 mM | 0.0578 mL | 0.2891 mL | 0.5782 mL | 1.4455 mL | |
| 50 mM | 0.0463 mL | 0.2313 mL | 0.4626 mL | 1.1564 mL | |
| 60 mM | 0.0385 mL | 0.1927 mL | 0.3855 mL | 0.9637 mL | |
| 80 mM | 0.0289 mL | 0.1445 mL | 0.2891 mL | 0.7227 mL | |
| 100 mM | 0.0231 mL | 0.1156 mL | 0.2313 mL | 0.5782 mL |
Iptriazopyrid Related Classifications
HY-174423 Related Classifications
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