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Cat. No.: HY-179539

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ISR activator 3

ISR activator 3 (Compound cc81) is the active metabolite of A8. ISR activator 3 activates the integrated stress response (ISR) by binding to RIG-I (K_D ≈ 0.55 μM), without inducing lipid droplet clearance. ISR activator 3 enhances the interferon response under viral mimicry signals. ISR activator 3 can be used for research on neurodegenerative diseases and immune stress.

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CAS No.: 332950-12-6
화학식: C₂₃H₂₁N₃O₃S₂
분자량:451.56

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

ISR activator 3 Chemical Structure

CAS No.: 332950-12-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

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Chemical Information

CAS No. 332950-12-6
분자량 451.56
화학식 C₂₃H₂₁N₃O₃S₂
SMILES

CC1=C2C(SC(C(NC3=C(C(OCC)=O)C(C4=CC=CC=C4)=CS3)=O)=C2N)=NC(C)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cuoco CA, et al. Pharmacological targeting of RIG-I can selectively activate the integrated stress response. Sci Adv. 2025 Oct 31;11(44):eadt3014. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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