country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-N11777

Copy Link Print Information

(−)-N-Hydroxyapiosporamide

(Synonyms: NHAP)

(−)-N-Hydroxyapiosporamide (NHAP), an alkaloid, is an NF-κB inhibitor with potent antitumor activity in vitro and in vivo. (−)-N-Hydroxyapiosporamide can be used for the research of colorectal cancer (CRC).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1205676-02-3
화학식: C₂₄H₃₁NO₇
분자량:445.51

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

(−)-N-Hydroxyapiosporamide Chemical Structure

CAS No.: 1205676-02-3

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All NF-κB Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.93 μM Compound: NHAP	Cytotoxicity against human HCT-116 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay Cytotoxicity against human HCT-116 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay	[PMID: 37243616]
HCT-116	IC₅₀	2.8 μM Compound: NHAP	Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay	[PMID: 37243616]
HCT-15	IC₅₀	0.57 μM Compound: NHAP	Cytotoxicity against human HCT-15 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay Cytotoxicity against human HCT-15 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay	[PMID: 37243616]
HT-29	IC₅₀	0.57 μM Compound: NHAP	Cytotoxicity against human HT-29 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay Cytotoxicity against human HT-29 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay	[PMID: 37243616]
HT-29	IC₅₀	0.61 μM Compound: NHAP	Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay	[PMID: 37243616]
RKO	IC₅₀	0.57 μM Compound: NHAP	Cytotoxicity against human RKO cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay Cytotoxicity against human RKO cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay	[PMID: 37243616]
SW480	IC₅₀	0.57 μM Compound: NHAP	Cytotoxicity against human SW480 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay Cytotoxicity against human SW480 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay	[PMID: 37243616]
SW-620	IC₅₀	0.57 μM Compound: NHAP	Cytotoxicity against human SW620 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay Cytotoxicity against human SW620 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay	[PMID: 37243616]

Chemical Information

CAS No. 1205676-02-3
분자량 445.51
화학식 C₂₄H₃₁NO₇
SMILES

O=C([C@]1([C@]2([C@@]([H])(C[C@@H](CC2)C)C=C[C@H]1C)[H])[H])C3=C(C([C@@]4([C@H]5[C@@H]([C@@H](CC4)O)O5)O)=CN(O)C3=O)O
Synonyms

NHAP
Structure Classification
- Alkaloids
- Pyridine Alkaloids
Initial Source
- Microorganisms
Apiospora montagnei
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Feng L, et al. The Natural Alkaloid (-)-N-Hydroxyapiosporamide Suppresses Colorectal Tumor Progression as an NF-κB Pathway Inhibitor by Targeting the TAK1-TRAF6 Complex. J Nat Prod. 2023 Jun 23;86(6):1449-1462. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

(−)-N-Hydroxyapiosporamide

All NF-κB Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

(−)-N-Hydroxyapiosporamide Related Classifications

HY-N11777 Related Classifications