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Cat. No.: HY-149094

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Neuroprotective agent 1

Neuroprotective agent 1 (2), a promising neuroprotective agent for the study of ischemic stroke, shows promising neuroprotective activity with the EC₅₀ value of 16.07 μM in the model of glutamate-induced excitotoxicity and 19.30 μM in the model of H₂O₂-induced oxidative damage.

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CAS No.: 2344786-13-4
화학식: C₃₂H₃₁NO₇
분자량:541.59

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Neuroprotective agent 1 Chemical Structure

CAS No.: 2344786-13-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
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Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
PC-12	EC₅₀	16.07 μM Compound: 2	Neuroprotective activity against glutamate induced excitotoxicity in rat PC12 cells pretreated with glutamate for 24 hrs followed by compound addition and measured after 24 hrs Neuroprotective activity against glutamate induced excitotoxicity in rat PC12 cells pretreated with glutamate for 24 hrs followed by compound addition and measured after 24 hrs	[PMID: 36921528]
PC-12	EC₅₀	19.3 μM Compound: 2	Neuroprotective activity against H2O2-induced oxidative damage in rat PC12 cells pretreated with H2O2 for 24 hrs followed by compound addition and measured after 24 hrs Neuroprotective activity against H2O2-induced oxidative damage in rat PC12 cells pretreated with H2O2 for 24 hrs followed by compound addition and measured after 24 hrs	[PMID: 36921528]
PC-12	IC₅₀	3.3 μM Compound: 2	Cytotoxicity against rat PC12 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against rat PC12 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 36921528]

Chemical Information

CAS No. 2344786-13-4
분자량 541.59
화학식 C₃₂H₃₁NO₇
SMILES

O=C(N(C)C1=CC=CC=C1)OC(C=C2OC3=C4C(O)=C5C=CC(C)(C)OC5=C3)=C(OC)C(C/C=C(C)\C)=C2C4=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yi-Li Chen, et al. Discovery of phenylcarbamoyl xanthone derivatives as potent neuroprotective agents for treating ischemic stroke. Eur J Med Chem. 2023 May 5;251:115251. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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