PSMA-HK9
PSMA-HK9 is a ligand targeting prostate-specific membrane antigen (PSMA) that binds to PSMA with high affinity, with a Kd value of 4.76 nM. PSMA-HK9 can be labeled with the diagnostic radionuclide 68Ga for imaging applications, and this labeled conjugate exhibits high tumor uptake and low normal tissue uptake in vivo. PSMA-HK9 can be labeled with the radionuclide 177Lu for targeted radionuclide studies, and this labeled conjugate possesses efficient cellular endocytosis and tumor inhibitory activity. PSMA-HK9 can be used in studies related to prostate cancer.
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- 화학식: C59H79N11O22
- 분자량:1294.32
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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PSMA 4.76 nM (Kd) |
PSMA-HK9 binds to purified PSMA protein with high affinity, with a Kd value of 4.76 nM and a predicted binding energy of -9.7 kcal·mol−1[1].
PSMA-HK9 (120 min) competitively inhibits PSMA binding in RM1-PSMA cells, with a Ki value of 0.50 nM, exhibiting high target specificity and affinity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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분자량 1294.32
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화학식 C59H79N11O22
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Sequence
{Tetraxetan}-{d-Glu}-{d-Glu}-{Amb}-{b-hAla(2-naphthyl)}-{d-Orn}-{CO}-{d-Glu}
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Sequence Shortening
{Tetraxetan}-{d-Glu}-{d-Glu}-{Amb}-{b-hAla(2-naphthyl)}-{d-Orn}-{CO}-{d-Glu}
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PSMA-HK9 Related Classifications
HY-P11893 Related Classifications
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