Vibralactones D-F from cultures of the basidiomycete Boreostereum vibrans

  • Chem Pharm Bull (Tokyo). 2010 Jan;58(1):113-6. doi: 10.1248/cpb.58.113.
Meng-Yuan Jiang  1 ,  Ling Zhang ,  Ze-Jun Dong ,  Zhu-Liang Yang ,  Ying Leng ,  Ji-Kai Liu
Affiliations
  • 1. Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
PMID: 20045978 DOI: 10.1248/cpb.58.113
Abstract

Three new metabolites, vibralactones D-F (1-3) were isolated from cultures of the basidiomycete Boreostereum vibrans. The relative configuration of 1 was established on the basis of X-ray diffraction analysis, while the absolute configurations of 1-3 were assigned using a modified Mosher's method. Compound 1 showed weak inhibitory activities against isozymes of 11beta-hydroxysteroid dehydrogenases (HSD) with IC(50) values of 85.7 microM (human HSD1), 295.2 microM (mouse HSD1), and 87.1 microM (human HSD2).

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