Antioxidative 2-(2-phenylethyl)chromones in Chinese eaglewood from Aquilaria sinensis

  • J Asian Nat Prod Res. 2020 Jul;22(7):639-646. doi: 10.1080/10286020.2019.1607841.
Chun-Ge Li  1 ,  Li Pan  1 ,  Zhu-Zhen Han  1 ,  Yan-Qiao Xie  1 ,  Hai-Jun Hu  1 ,  Xiao-Long Liu  1 ,  Li-Hong Wu  2 ,  Li Yang  1 ,  Zheng-Tao Wang  1  2
Affiliations
  • 1. The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • 2. Shanghai R&D Centre for Standardization of Chinese Medicines, Shanghai 201210, China.
PMID: 31056992 DOI: 10.1080/10286020.2019.1607841
Abstract

Two new compounds 6,7-dimethoxy-2-[2-(2'-hydroxyphenyl)ethyl]chromone (1) and 6,7-dimethoxy-2-[2-(4'-hydroxyphenyl)ethenyl]chromone (2), together with ten known 2-(2-phenylethyl)chromones (3-12) were isolated from the resinous wood of Aquilaria sinensis (Lour.) Gilg. Their structures were elucidated by detailed IR, MS, NMR spectroscopic analyses, and comparison with reported. The absolute configuration of 3 was confirmed by Cu Kα X-ray crystallographic experiment, and the X-ray crystallographic data of 3 were firstly reported. Compounds 2, 8, 10, and 11 exhibited strong ABTS•+ radical scavenging activity, with IC50 values of 12.3, 16.5, 12.1, and 34.7 μM, respectively.[Formula: see text].

Keywords
2-(2-phenylethyl)chromones; ABTS•+ radical scavenging activity; Aquilaria sinensis; Chinese eaglewood; antioxidant activity.
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