Spectanoids A-H: Eight undescribed sesterterpenoids from Aspergillus spectabilis

  • Phytochemistry. 2021 Nov;191:112910. doi: 10.1016/j.phytochem.2021.112910.
Mengsha Wei  1 ,  Peng Zhou  1 ,  Liping Huang  1 ,  Jie Yin  1 ,  Qin Li  1 ,  Chong Dai  1 ,  Jianping Wang  1 ,  Lianghu Gu  2 ,  Qingyi Tong  3 ,  Hucheng Zhu  4 ,  Yonghui Zhang  5
Affiliations
  • 1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
  • 2. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: [email protected].
  • 3. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: [email protected].
  • 4. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: [email protected].
  • 5. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: [email protected].
PMID: 34481345 DOI: 10.1016/j.phytochem.2021.112910
Abstract

Ten sesterterpenoids, including eight undescribed ones named spectanoids A-H and two known analogs, were obtained from Aspergillus spectabilis. Their structures, including absolute configurations, were determined based on HRESIMS, NMR, ECD calculations and single-crystal X-ray diffraction analyses. Spectanoids A-G are tricyclic sesterterpenoids with an unusual 5/12/5 ring system, while spectanoid H possesses a 5/8/6/5 ring system. All of these compounds were evaluated for their cytotoxic activities against three human Cancer cells, and spectanoid A, spectanoid C and spectanoid F exhibited moderate cytotoxic activities with IC50 values ranging from 12.1 to 26.1 μM.

Keywords
Aspergillaceae; Aspergillus spectabilis; Cytotoxic activities; Sesterterpenoids.
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