RET-IN-23
RET-IN-23 (compound 17) is a potent and orally active RET inhibitor with IC50 values of 1.32, 2.50, 6.54, 1.03, 1.47 nM for RET-WT, RET-CCDC6, RET-V804L, RET-V804M, RET-M918T, respectively. RET-IN-23 shows anti-tumor activity.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 2479961-46-9
- 화학식: C28H28FN11
- 분자량:537.59
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
IC50: 1.32 nM (RET-WT); 2.50 nM (RET-CCDC6); 6.54 nM (RET-V804L); 1.03 nM (RET-V804M); 1.47 nM (RET-M918T)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c-nu mouse (TT cell subcutaneous xenograft tumor)[1]
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Dosage:5 mg/kg
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Administration:P.o.
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Result:Showed anti-tumor activity with T/C of 17.44%, TGI of 88.82%.
Chemical Information
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CAS No. 2479961-46-9
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분자량 537.59
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화학식 C28H28FN11
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SMILES
CC1=CC(NC2=NNC(C)=C2)=NC(C3=CC=C(N4CC(C5)N(CC6=CC=C(N7C=C(F)C=N7)N=C6)C5C4)N=C3)=N1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RET-IN-23 Related Classifications
HY-153676 Related Classifications
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